Registration Dossier
Registration Dossier
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EC number: 272-727-3 | CAS number: 68909-99-9
Endpoint summary
Administrative data
Description of key information
No skin/eye irritation/corrosion studies of registered substance were available. The registered substance is a complex reaction mixture, containing N,N'-bis(3-aminopropyl)ethylenediamine (CAS No. 10563-26-5) and N-(2-aminoethyl)-1,3-propanediamine (CAS No. 13531-52-7) among others as majors components. These two components were used as surrogate to evaluate the skin/eye irritation/corrosion potential of the registered substance. For read across justification please refer to IUCLID chapter 13.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
Two skin irritation/corrosion studies are available for surrogates of the registered substance, both of validity 2 (BASF- XXVI/99 and BASFAG.XXVI/100). In the two studies, the test substance was shown to be corrosive to the rabbit skin/caused severe skin irritation.
In the BASF study with N-(2-aminoethyl)-1,3-propanediamine (CAS No. 13531-52-7), the a primary skin irritation evaluated in rabbits with undiluted test substance (exposure times of 1, 5 and 15 min and 20 hours) in a study design similar to the OECD guideline 404. Necrosis was observed irrespective of the exposure duration and both animals tested died within two days.
Eye irritation:
In a primary eye irritation study in rabbits conducted with the same surrogate as above, 50 µL of the test substance were applied to the conjunctival sac of one eye in 2 animals. Necrosis, staphyloma were also observable and not completely reversible at the end of the 8 days observation period.
Respiratory irritation:
No data
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Based on the above described studies and considering the worst case assumption that the test substance contains 100% of its most toxic surrogate the test substance should be classified according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 as follows:
corrosive to skin and eyes (GHS cat. 1A)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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