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EC number: 225-200-7 | CAS number: 4711-68-6
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study was carried out according to test guidline and under GLP-conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4'-ethoxy-3-hydroxy-2-naphthanilide
- EC Number:
- 225-200-7
- EC Name:
- 4'-ethoxy-3-hydroxy-2-naphthanilide
- Cas Number:
- 4711-68-6
- Molecular formula:
- C19H17NO3
- IUPAC Name:
- N-(4-ethoxyphenyl)-3-hydroxy-2-naphthamide
Constituent 1
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
Study design
- Test type:
- static
- Limit test:
- yes
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 2.3 - 2.5 mmol Ca2+ + Mg2+/L
- Test temperature:
- 21.5 - 22-3
- pH:
- 7.7 -7.9
- Dissolved oxygen:
- 7.2 - 8.6 mg/L
- Nominal and measured concentrations:
- 0/10000 mg/L (nominal)
0/0.2 mg/L (mean of measured conc.) - Details on test conditions:
- use of reconstituted water, composition acc. to ISO/DIS 7346/1
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: lethality value based on loading rates (nominal conc.); mean value of measured concentrations: 0.2 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: lethality value based on loading rates (nominal conc.); mean value of measured concentrations: 0.2 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Remarks on result:
- other: not determined
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 67/548/EEC: Acute aquatic toxicity: no classification
1272/2008/EC: Acute aquatic toxicity: no classification - Executive summary:
No lethality was observed up to the solubility limit of Naphtol AS-VL. The 10000 mg/L (0.2 mg/L*) group exhibited reversible symptoms.
* = value based on the mean of analytically determined values
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