Quinine hydrogen sulphate

Toxicity to aquatic algae and cyanobacteria

Description of key information

The determined EC50 of quinine sulphate for green algae Dunaliella salina is 14.5 mg/L. The lowest calculated EC50, 96 h for green algae of Quinine bisulphate is 21.568 g/L. The lowest chronic toxicity value estimated by calculation is 3.766 g/L.

Key value for chemical safety assessment

EC50 for freshwater algae:

32.028 g/L

EC50 for marine water algae:

14.5 mg/L

EC10 or NOEC for freshwater algae:

5.404 g/L

EC10 or NOEC for marine water algae:

5.404 g/L

Additional information

This experimental study was published by Moreno-Garrido, 2001. In this publication, the toxicity for green algae Dunaliella salina was determined for 72 h in saltwater. The determined EC50 of quinine sulphate is 14.5 mg/L. The toxicity (LC50, 96 h and chronic toxicity value) is estimated by using ECOSAR v1.11. Lowest EC50 and chronic toxicity value, were observed for green algae by ECOSAR class Benzyl Alcohols at 32.928 g/L and 5.404 g/L, respectively. The calculated values for Neutral Organic Structure Analysis Relationship (baseline toxicity) for green algae are 123 g/L (LC50) and 13.486 g/L (chronic toxicity value). The high values reflect the low toxicity. The EPA recommends that empirical measures provide better results. However, empirical studies have not been done, so that we adapt the prediction.