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EC number: 611-631-1 | CAS number: 58190-57-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The analogue substance Wasox-VMAC2, which shares the same functional groups with EAC, also has comparable values for the relevant molecular properties and therefore, both are expected to be toxicologically equivalent for the genetic toxicity
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: Read-across
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
- Principles of method if other than guideline:
- Read-across approach from experimental data (OECD Guideline 474, GLP study) with analogue substance Wasox-VMAC2.
- GLP compliance:
- no
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- acetone O,O'-[methoxy(vinyl)silanediyl]oxime; acetone O,O',O''-(vinylsilanetriyl)oxime and acetone O-[dimethoxy(vinyl)silyl]oxime
- IUPAC Name:
- acetone O,O'-[methoxy(vinyl)silanediyl]oxime; acetone O,O',O''-(vinylsilanetriyl)oxime and acetone O-[dimethoxy(vinyl)silyl]oxime
- Reference substance name:
- 797751-44-1
- Cas Number:
- 797751-44-1
- IUPAC Name:
- 797751-44-1
- Reference substance name:
- A mixture of: propan-2-one-O,O'(methoxyvinylsilandiyl)dioxime; propan-2-one-O-(dimethoxyvinylsilyl)oxime; propan-2-one-O,O',O''-(vinylsilantriyl)trioxime
- EC Number:
- 458-680-3
- EC Name:
- A mixture of: propan-2-one-O,O'(methoxyvinylsilandiyl)dioxime; propan-2-one-O-(dimethoxyvinylsilyl)oxime; propan-2-one-O,O',O''-(vinylsilantriyl)trioxime
- IUPAC Name:
- 458-680-3
- Details on test material:
- - Name of test material (as cited in study report): Wasox-VMAC2
- Molecular formula (if other than submission substance): Not applicable, multiconstituent substance
- Molecular weight (if other than submission substance): 231.627
- Smiles notation (if other than submission substance): Not applicable, multiconstituent substance
- InChl (if other than submission substance): Not applicable, multiconstituent substance
- Structural formula attached as image file (if other than submission substance): see Fig.
Constituent 1
Constituent 2
Constituent 3
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Remarks:
- (at estimated doses of 799.26, 1198.90 and 1598.53 mg/kg)
- Toxicity:
- no effects
- Remarks:
- (at estimated doses of 1598.53 mg/kg)
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- Based on the experimental data on the analogue substance Wasox-VMAC2 which did not produce relevant increases of the number of micronuclei in polychromatic erythrocytes in mice of either sex at doses of 1000, 1500 and 2000 mg/kg bw and sampling times of 24 and 48 h, the read-across approach was applied and EAC3 was also considered not to produce micronuclei increases in polychromatic erythrocytes under test conditions.
Any other information on results incl. tables
See "Data Matrix" and "Reporting Format" attached.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Based on read-across approach from experimental results on analogue Wasox-VMAC2 (OECD Guideline 474, GLP study, test item EAC3 was considered not to produce relevant increase of the number of micronuclei in polychromatic erythrocytes under test conditions. - Executive summary:
Based on the experimental data (test method according to OECD Guideline 474 and GLP) on the analogue substance Wasox-VMAC2 which did not produce relevant increases of the number of micronuclei in polychromatic erythrocytes in mice of either sex at doses of 1000, 1500 and 2000 mg/kg bw and sampling times of 24 and 48 h, the read-across approach was applied and EAC3 was also considered not to produce micronuclei increases in polychromatic erythrocytes under test conditions.
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