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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The analogue substance Wasox-VMAC2, which shares the same functional groups with EAC, also has comparable values for the relevant molecular properties and therefore, both are expected to be toxicologically equivalent for the genetic toxicity
Cross-reference
Reason / purpose for cross-reference:
reference to other study

Data source

Reference
Reference Type:
other: Read-across
Title:
Unnamed
Year:
2012

Materials and methods

Principles of method if other than guideline:
Read-across approach from experimental data (OECD Guideline 474, GLP study) with analogue substance Wasox-VMAC2.
GLP compliance:
no
Type of assay:
micronucleus assay

Test material

Constituent 1
Reference substance name:
acetone O,O'-[methoxy(vinyl)silanediyl]oxime; acetone O,O',O''-(vinylsilanetriyl)oxime and acetone O-[dimethoxy(vinyl)silyl]oxime
IUPAC Name:
acetone O,O'-[methoxy(vinyl)silanediyl]oxime; acetone O,O',O''-(vinylsilanetriyl)oxime and acetone O-[dimethoxy(vinyl)silyl]oxime
Constituent 2
Reference substance name:
797751-44-1
Cas Number:
797751-44-1
IUPAC Name:
797751-44-1
Constituent 3
Reference substance name:
A mixture of: propan-2-one-O,O'(methoxyvinylsilandiyl)dioxime; propan-2-one-O-(dimethoxyvinylsilyl)oxime; propan-2-one-O,O',O''-(vinylsilantriyl)trioxime
EC Number:
458-680-3
EC Name:
A mixture of: propan-2-one-O,O'(methoxyvinylsilandiyl)dioxime; propan-2-one-O-(dimethoxyvinylsilyl)oxime; propan-2-one-O,O',O''-(vinylsilantriyl)trioxime
IUPAC Name:
458-680-3
Details on test material:
- Name of test material (as cited in study report): Wasox-VMAC2
- Molecular formula (if other than submission substance): Not applicable, multiconstituent substance
- Molecular weight (if other than submission substance): 231.627
- Smiles notation (if other than submission substance): Not applicable, multiconstituent substance
- InChl (if other than submission substance): Not applicable, multiconstituent substance
- Structural formula attached as image file (if other than submission substance): see Fig.

Results and discussion

Test results
Sex:
male/female
Genotoxicity:
negative
Remarks:
(at estimated doses of 799.26, 1198.90 and 1598.53 mg/kg)
Toxicity:
no effects
Remarks:
(at estimated doses of 1598.53 mg/kg)
Vehicle controls validity:
valid
Positive controls validity:
valid
Additional information on results:
Based on the experimental data on the analogue substance Wasox-VMAC2 which did not produce relevant increases of the number of micronuclei in polychromatic erythrocytes in mice of either sex at doses of 1000, 1500 and 2000 mg/kg bw and sampling times of 24 and 48 h, the read-across approach was applied and EAC3 was also considered not to produce micronuclei increases in polychromatic erythrocytes under test conditions.

Any other information on results incl. tables

See "Data Matrix" and "Reporting Format" attached.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
Based on read-across approach from experimental results on analogue Wasox-VMAC2 (OECD Guideline 474, GLP study, test item EAC3 was considered not to produce relevant increase of the number of micronuclei in polychromatic erythrocytes under test conditions.
Executive summary:

Based on the experimental data (test method according to OECD Guideline 474 and GLP) on the analogue substance Wasox-VMAC2 which did not produce relevant increases of the number of micronuclei in polychromatic erythrocytes in mice of either sex at doses of 1000, 1500 and 2000 mg/kg bw and sampling times of 24 and 48 h, the read-across approach was applied and EAC3 was also considered not to produce micronuclei increases in polychromatic erythrocytes under test conditions.