Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: NON-GLP screening test

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report date:
2007

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
Deviations:
yes
Remarks:
Screening Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenylephrine hydrochloride
EC Number:
200-517-3
EC Name:
Phenylephrine hydrochloride
Cas Number:
61-76-7
Molecular formula:
C9H13NO2.ClH
IUPAC Name:
phenylephrine hydrochloride
Constituent 2
Reference substance name:
Phenylephrin hydrochloride
IUPAC Name:
Phenylephrin hydrochloride
Test material form:
not specified

Test organisms

Test organisms (species):
activated sludge, domestic

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
180 min

Results and discussion

Effect concentrationsopen allclose all
Duration:
180 min
Dose descriptor:
other: EC20
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Duration:
180 min
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate

Applicant's summary and conclusion