Registration Dossier
Registration Dossier
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EC number: 939-525-3 | CAS number: 1471313-03-7
Endpoint summary
Administrative data
Description of key information
Oral: LD50 > 6700 mg/kg bw for rat; LD50 > 8900 mg/kg bw for mouse
Dermal: LD50 > 2000 mg/kg bw for rat (limit test)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 8 900 mg/kg bw
- Quality of whole database:
- Both studies have limitations (lack of details on experimental conditions) and were performed before GLP exist but they have concordant results in two different species (rats and mice).
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Study with Klimisch score 1 performed in compliance with GLP and OECD guideline 402.
Additional information
No mortality was observed in mice up to 10 mL/kg bw; this result was confirmed in rats where low mortality (1/5 animals) was observed at 7.5 mL/ kg bw. Also, the high dermal LD50 (>2000 mg/kg bw) confirms the low acute toxicity potential that has been demonstrated by oral exposure in mice and rats. Rodents species are generally used to assess this endpoint, therefore those results should be relevant to humans.
Justification for selection of acute toxicity – oral endpoint
Better quality and more details are reported in the report compared to the other study available.
Justification for selection of acute toxicity – dermal endpoint
Only one study available
Justification for classification or non-classification
Oral and dermal LD50 are higher than 2000 mg/kg bw in mice and/or rats. Therefore the substance is not classified according to Directive 67/548/EEC and CLP Regulation (EC) N° 1272 /2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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