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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicity of several derivatives of aromatic amines
Author:
Silaev AA et.al.
Year:
1996
Bibliographic source:
Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology.Volume/page/year: (10),36,1996
Reference Type:
review article or handbook
Title:
RTECS Number : DB4979000
Author:
RTECS Database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):-Silaev AA et.al.; Toxicity of several derivatives of aromatic amines; MTPEEI Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology.Volume/page/year: (10),36,1996
Reference Type:
other: Authoritative data base
Title:
ACToR no: 350108
Author:
ACToR Database
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource):- Silaev AA et.al.; Toxicity of several derivatives of aromatic amines; Meditsina Truda i Promyshlennaya Ekologiya. Industrial Medicine and Ecology. Vol. (10), Pg. 36, 1996.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Standard acute method
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium 3-methylsulphanilate
EC Number:
264-172-0
EC Name:
Sodium 3-methylsulphanilate
Cas Number:
63450-43-1
Molecular formula:
C7H9NO3S.Na
IUPAC Name:
sodium 3-methylsulphanilate
Details on test material:
- Name of test material: sodium 3-methylsulphanilate
- Substance type:organic
- Physical state:solid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: LD
Effect level:
> 15 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Details of toxic effects not reported other than lethal dose value

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral median lethal dose (LD) of sodium 3-methylsulphanilate in rat was found to be >15000 mg/kg of body weight. Acute toxicity of sodium 3-methylsulphanilate to rat by the oral route indicates that the substance does not exhibits acute toxicity by the oral route.
Executive summary:

The acute oral median lethal dose (LD) of sodium 3-methylsulphanilate in rat was found to be >15000 mg/kg of body weight. Acute toxicity of sodium 3-methylsulphanilate to rat by the oral route indicates that the substance does not exhibits acute toxicity by the oral route.