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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation in aquatic species: fish
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3
Justification for type of information:
JUSTIFICATION FOR DATA WAIVING
In accordance with Column 2 of REACH Annex IX, the study does not need to be conducted since the substance is expected to have a low potential for bioaccumulation (Log Kow < 3).
Reason / purpose:
data waiving: supporting information
Reason / purpose:
data waiving: supporting information
Reason / purpose:
data waiving: supporting information
Reason / purpose:
data waiving: supporting information
Reason / purpose:
data waiving: supporting information

Description of key information

Data waiving (study scientifically not necessary/other information available): In accordance with Column 2 of REACH Annex IX, the study does not need to be conducted since the substance is expected to have a low potential for bioaccumulation (Log Kow<3).

Key value for chemical safety assessment

BCF (aquatic species):
3.162 L/kg ww

Additional information

Data waiving (study scientifically not necessary/other information available): In accordance with Column 2 of REACH Annex IX, these studies do not need to be conducted since the substance is expected to have a low potential for bioaccumulation (Log Kow <3).

Supporting studies: Bioaccumulation (BCF) of main consituents has been calculated by EPI-Suite, EPA (USA), BCFBAF v3.01:

2-[3-(2{3-[4,5-dihydroxy-1,3-dioxolan-2-yl)(hydroxy)methyl]-4,5-dihydroxy-2-oxoimidazolidin-1-yl}-1,2-dihydroxyethyl)-4,5-dihydroxy-2-oxoimidazolidin-1-yl]-2-hydroxyacetaldehyde: The BCF of the substance was estimated to be 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).

2-[4,5-dihydroxy-3-(1-hydroxy-2-oxoethyl)-2-oxoimidazolidin-1-yl]-2-hydroxyacetaldehyde: The BCF of the substance was estimated to be 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).

4,5-dihydroxyimidazolidin-2-one: The BCF of the substance was estimated to be 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).

(2S)-2-[(4S,5S)-3-[(S)-[(4R,5R)-4,5-dihydroxy-1,3-dioxolan-2-yl](hydroxy)methyl]-4,5-dihydroxy-2-oxoimidazolidin-1-yl]-2-hydroxyacetaldehyde: The BCF of the substance was estimated to be 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).

1-{2-[4,5-dihydroxy-3-(1-hydroxy-2-oxoehtyl)-2-oxoimidazolidin-1-yl]-1,2-dihydroxyethyl}-3-(1,2-dihydroxyethyl)urea: The BCF of the substance was estimated to be 3.162 L/kg wet-wt (log BCF from regression-based method = 0.500).