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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two hydrolysis studies as-
2. and 3.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Duration:
5 d
Temp.:
50 °C
Remarks:
2. Study was performed at different pH range, i.e., at pH 4, 7 and 9, respectively.
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Temp.:
50 °C
Type:
not specified
Remarks on result:
other: 2.Hydrolysis half-life value of test chemical was not known, but hydrolysis of test chemical did not reach > 10% in any of the pH systems (i.e., at pH 4, 7 and 9, respectively) and thus the preliminary study was terminated.
Remarks on result:
other: 3. test chemical is stable for hydrolysis
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis he hydrolysis of test chemical did not reach > 10% in any of the pH system. Thus, based on this % value, it can be concluded that the test chemical not hydrolysable in water.
Executive summary:

Data available for the test chemical has been reviewed from authoritative database (OECD SIDS report and HSDB, 2018) to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

The first study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. As the hydrolysis of test chemical did not reach > 10% in any of the pH systems, the preliminary study was terminated. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days. Based on this, it is concluded that the test substance is not hydrolysable.

Next study was reviewed from authoritative database (HSDB) it is concluded that the test chemical is stable to hydrolysis that means it is not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis he hydrolysis of test chemical did not reach > 10% in any of the pH system. Thus, based on this % value, it can be concluded that the test chemical not hydrolysable in water.

Description of key information

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis he hydrolysis of test chemical did not reach > 10% in any of the pH system. Thus, based on this % value, it can be concluded that the test chemical not hydrolysable in water.

Key value for chemical safety assessment

Additional information

Data available for the test chemical has been reviewed from authoritative database (OECD SIDS report and HSDB, 2018) to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

The first study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C. As the hydrolysis of test chemical did not reach > 10% in any of the pH systems, the preliminary study was terminated. Test chemical was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days. Based on this, it is concluded that the test substance is not hydrolysable.

Next study was reviewed from authoritative database (HSDB) it is concluded that the test chemical is stable to hydrolysis that means it is not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis he hydrolysis of test chemical did not reach > 10% in any of the pH system. Thus, based on this % value, it can be concluded that the test chemical not hydrolysable in water.