Registration Dossier
Registration Dossier
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EC number: 205-207-1 | CAS number: 135-63-7
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: testing method performed according to OECD107
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- not specified
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 5'-chloro-3-hydroxy-2'-methyl-2-naphthanilide
- EC Number:
- 205-207-1
- EC Name:
- 5'-chloro-3-hydroxy-2'-methyl-2-naphthanilide
- Cas Number:
- 135-63-7
- Molecular formula:
- C18H14ClNO2
- IUPAC Name:
- N-(5-chloro-2-methylphenyl)-3-hydroxy-2-naphthamide
Constituent 1
Study design
- Analytical method:
- photometric method
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 2.8
- Temp.:
- 23 °C
- pH:
- ca. 7.8
Any other information on results incl. tables
Table 1: Results in detail
determ. no. |
stock solution [ml] | n-octanol [ml] | test substance conc. in n-octanol phase [mg/l] | test substance conc. in water phase [mg/l] | log Pow |
A1 |
5 | 10 | 1193,3 | 0,90 | 3,1 |
| A2 | 5 | 10 | 1186,5 | 1,18 | 3,0 |
B1 |
10 | 10 | 1185,4 | 1,67 | 2,9 |
| B2 | 10 | 10 | 1177,8 | 1,70 | 2,8 |
| C1 | 20 | 10 | 1178,2 | 2,73 | 2,6 |
| C2 | 20 | 10 | 1180,1 | 2,66 | 2,6 |
mean |
--- | --- | --- | --- | 2,8 |
Stock solution: 1186 mg/l
Conc. of filtered stock solution: 1152 mg/l
Applicant's summary and conclusion
- Conclusions:
- Due to the partition coefficient n-octanol-water bioaccumulation is not expected.
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