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Long-term toxicity to fish

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Description of key information

Waiving argument:  Long-term toxicity testing in fish appears to be scientifically unnecessary, as data for a more sensitive species of a different trophic level is available.

Key value for chemical safety assessment

Additional information

For regulatory purposes as well as for environmental risk assessment, only the lowest toxicity value in species from three trophic levels is considered (see Guidance on information requirements and chemical safety assessment, Chapter R.7b: Endpoint specific guidance, section 7.8.5, p. 41 - Threshold approach for toxicity testing in fish).

Short-term toxicity tests with diisopropylnaphthalene, available for species of three trophic levels (invertebrates, aquatic plants and fish), suggest that Daphnia is the most sensitive species (EC0 values being lower by a factor of 2 to 3 compared to the LC0 values in fish (EC/LC50 was not reached within the water solubility of diisopropylnaphthalene).

Long-term toxicity tests are available for daphnia (fresh water) and Acartia tonsa (sea water). Based on the sensitivity observed in short term tests, it is estimated that in long-term tests daphnia will also be the most sensitive species. Thus classification and derivation of PNECs will be based on long-term NOEC obtained in invertebrate tests.