Registration Dossier

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

NOELR (21 d) ≥ 10 mg/L (Daphnia magna, EU Method C.20)

Key value for chemical safety assessment

Additional information

The chronic toxicity of Glycerides, C8-21 and C8-21-unsatd., mono- and di-, acetates (CAS No. 97593-30-1) to aquatic invertebrates was investigated in a study by Richter (2012). This test was conducted according to EU Method C.20 (Daphnia magnaReproduction Test), under GLP conditions.Daphnia magna was exposed to the test substance for 21 days within a semi-static water regime and test concentrations (2.1, 4.5 and 10 mg/L, loading rates) were followed by GC and DOC analysis. GC analysis of dissolved and undissolved test solution at 10 mg/L before the final filtration step resulted in test concentrations close to nominal values. During the testing period (performed with the filtered test solutions, without the undissolved fraction), measured concentrations remained below the limit of detection (LOD) of both GC (0.070 mg/L) and DOC (2 mg/L) methods. The water solubility of the substance was tested at 100 and 1000 mg/L, resulting in values of 3.5 and 21.9 mg/L, respectively. Nevertheless, differences in solubility of substances in pure water (water solubility test) and test medium (aquatic test) can be expected. Furthermore, considering that Glycerides, C8-21 and C8-21-unsatd., mono- and di-, acetates is expected to show high adsorption potential (log Koc values 3.7-4.2), most probably a significant fraction of test material was adsorbed to the filter. Nevertheless, since the Water Accomodated Fraction (WAF) was performed, probably the adsorbed fraction of the substance also corresponded to the undissolved test material, and only the water soluble fraction was present in the test solution. After 21 days of exposure, no effects on survival or reproduction were observed, resulting in a NOELR (21 d)≥ 10 mg/L.

In conclusion, no effects were observed up to the maximum achievable concentration in test medium.