Sorbitan monostearate, ethoxylated

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

Experimental data of various test chemicals

Justification for type of information:

Experimental data of various test chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: Refer below principle

Principles of method if other than guideline:

WoE report is prepared based on two short term toxicity study of the test chemical on aquatic invertebrate.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

yes

Test organisms (species):

Daphnia magna

Details on test organisms:

- Common name: Water flea

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Reference substance (positive control):

not specified

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 13 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 1ST STUDY

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

19 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 2nd study

Validity criteria fulfilled:

no

Conclusions:

1: After the exposure period of 48 hrs, effect of test chemical on the mobility of daphnia magna were studied and determine at > 13 mg/l.
2: After the exposure period of 48 hrs, effect of test chemical on the mobility of daphnia magna was determine at 19 mg/l.
Thus based on the above effect, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

Executive summary:

Summarized result for the toxicity of test chemical were studied and mention as below:

Short term toxicity study of test chemical on the mobility of daphnia magna were carried out in accordance with the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). Test conducted under the static system for 48 hrs. After the exposure period of 48 hrs, effect of test chemical on the mobility of daphnia magna were studied and determine at > 13 mg/l. As the test chemical is readily biodegradable in water, thus on that basis chemical consider to be nontoxic and not classified as per the CLP classification criteria.

First study was supported by the second study from authoritative database. Objective of the study was evaluation of effects of test chemical on daphnia magna. Test carried out in accordance with the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). Static system were used. After the exposure period of 48 hrs, effect of test chemical on the mobility of daphnia magna was determine at 19 mg/l. As the test chemical is readily biodegradable in water, thus on that basis chemical consider to be nontoxic and not classified as per the CLP classification criteria.

Thus based on the above effect, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

Description of key information

1: After the exposure period of 48 hrs, effect of test chemical on the mobility of daphnia magna were studied and determine at > 13 mg/l.

2: After the exposure period of 48 hrs, effect of test chemical on the mobility of daphnia magna was determine at 19 mg/l.

Thus based on the above effect, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

19 mg/L

Additional information

Summarized result for the toxicity of test chemical and structually and functionally similar read across chemicals, study has been reviewed and mention as below:

Short term toxicity study of test chemical on the mobility of daphnia magna were carried out in accordance with the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). Test conducted under the static system for 48 hrs. After the exposure period of 48 hrs, effect of test chemical on the mobility of daphnia magna were studied and determine at > 13 mg/l. As the test chemical is readily biodegradable in water, thus on that basis chemical consider to be nontoxic and not classified as per the CLP classification criteria.

First study was supported by the second study from authoritative database. Objective of the study was evaluation of effects of test chemical on daphnia magna. Test carried out in accordance with the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). Static system were used. After the exposure period of 48 hrs, effect of test chemical on the mobility of daphnia magna was determine at 19 mg/l. As the test chemical is readily biodegradable in water, thus on that basis chemical consider to be nontoxic and not classified as per the CLP classification criteria.

Thus based on the above effect, chemical consider to be nontoxic and not classified as per the CLP classification criteria.