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EC number: 500-020-4 | CAS number: 9005-67-8 1 - 6.5 moles ethoxylated
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Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
- Justification for type of information:
- Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below
- Principles of method if other than guideline:
- The effect of test chemical on methanogenesis and the microbial reductive dechlorination of hexachlorobenzene (HCB) was examined using three anaerobic, HCB-dechlorinating mixed cultures, one glucose fed and two lactate fed, that were derived from contaminated estuarine sediments. The two lactate-fed cultures differed significantly in their metabolic activity, especially with respect to the rate and extent of HCB reductive dechlorination. The objective of the study was to screen and select biologically compatible surfactants for use in subsequent research on surfactant-enhanced bioavailability of sorbed-phase chlorinated organic contaminants.
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Vehicle:
- not specified
- Test organisms (species):
- anaerobic microorganisms
- Details on inoculum:
- using contaminated estuarine sediments as inoculum.
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 82 d
- Test temperature:
- 22° C
- Nominal and measured concentrations:
- 10 to 1000 mg/L.
- Details on test conditions:
- The mixed cultures were developed at 22° using contaminated estuarine sediments as inoculum. One culture received glucose and the other two lactate as the carbon source. One of the lactate-fed cultures exhibited slow dechlorination activity while the other actively dechlorinated HCB. Reductive
dechlorination assays were performed at surfactant concns. ranging from 10 to 1000 mg/L. - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 82 d
- Dose descriptor:
- EC50
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- other: dechlorination rate
- Remarks on result:
- other: Other details not known
- Details on results:
- The effect of test chemical on the reductive dechlorination of hexachlorobenzene (HCB) was examimed using three anaerobic HCB-dechlorinating enriched cultures.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the above effects observations, the EC was determine to be 50 mg/l.
- Executive summary:
The effect of test chemical on methanogenesis and the microbial reductive dechlorination of hexachlorobenzene (HCB) was examined using three anaerobic, HCB-dechlorinating mixed cultures, one glucose fed and two lactate fed, that were derived from contaminated estuarine sediments. The two lactate-fed cultures differed significantly in their metabolic activity, especially with respect to the rate and extent of HCB reductive dechlorination. The objective of the study was to screen and select biologically compatible surfactants for use in subsequent research on surfactant-enhanced bioavailability of sorbed-phase chlorinated organic contaminants. The effect of test chemical on the reductive dechlorination of hexachlorobenzene (HCB) was examimed using three anaerobic HCB-dechlorinating enriched cultures. Based on the above effects observations, the EC was determine to be 50 mg/l.
Reference
Description of key information
The effect of test chemical on methanogenesis and the microbial reductive dechlorination of hexachlorobenzene (HCB) was examined using three anaerobic, HCB-dechlorinating mixed cultures, one glucose fed and two lactate fed, that were derived from contaminated estuarine sediments. The two lactate-fed cultures differed significantly in their metabolic activity, especially with respect to the rate and extent of HCB reductive dechlorination. The objective of the study was to screen and select biologically compatible surfactants for use in subsequent research on surfactant-enhanced bioavailability of sorbed-phase chlorinated organic contaminants. The effect of test chemical on the reductive dechlorination of hexachlorobenzene (HCB) was examimed using three anaerobic HCB-dechlorinating enriched cultures. Based on the above effects observations, the EC was determine to be 50 mg/l.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 50 mg/L
Additional information
The effect of test chemical on methanogenesis and the microbial reductive dechlorination of hexachlorobenzene (HCB) was examined using three anaerobic, HCB-dechlorinating mixed cultures, one glucose fed and two lactate fed, that were derived from contaminated estuarine sediments. The two lactate-fed cultures differed significantly in their metabolic activity, especially with respect to the rate and extent of HCB reductive dechlorination. The objective of the study was to screen and select biologically compatible surfactants for use in subsequent research on surfactant-enhanced bioavailability of sorbed-phase chlorinated organic contaminants. The effect of test chemical on the reductive dechlorination of hexachlorobenzene (HCB) was examimed using three anaerobic HCB-dechlorinating enriched cultures. Based on the above effects observations, the EC was determine to be 50 mg/l.
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