Registration Dossier
Registration Dossier
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EC number: 277-335-6 | CAS number: 73263-40-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Review of published data, most of which was produced prior introduction of GLP and OECD testing guiedelines.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Concise International Chemical Assessment Document 77, Strontium and Strontium Compounds
- Author:
- UNEP
- Year:
- 2 010
- Bibliographic source:
- http://www.who.int/ipcs/en/
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Review on all available experimental data on ADME
- GLP compliance:
- no
Test material
- Reference substance name:
- Strontium and Strontium compounds
- IUPAC Name:
- Strontium and Strontium compounds
- Reference substance name:
- Strontium chloride
- EC Number:
- 233-971-6
- EC Name:
- Strontium chloride
- Cas Number:
- 10476-85-4
- IUPAC Name:
- strontium dichloride
Constituent 1
Constituent 2
- Radiolabelling:
- other: 90-Sr or unlabelled material
Test animals
- Species:
- other: human, rat, dog
- Sex:
- male/female
Results and discussion
Main ADME resultsopen allclose all
- Type:
- distribution
- Results:
- Strontium is incorporated into bone.
- Type:
- absorption
- Results:
- Absorption occurs after inhalation and ingestion. Undamaged skin appears to be an effective barrier.
- Type:
- excretion
- Results:
- Strontium is excreted in urine and feces.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Strontium chloride and soluble strontium compounds are absorbed after ingestion and inhalation. Undamaged skin appears to be an effective barrier.
- Details on distribution in tissues:
- Strontium is transported in the plasma and detected in all body fluids. It is partly incorporated into bone.
- Details on excretion:
- Excretion occurs both via urine and feces. Elimination from Strontium incorporated into bone is slow.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
