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Registration Dossier
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EC number: 207-325-9 | CAS number: 462-34-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- testing lab.
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Trifluoro(tetrahydrofuran)boron
- EC Number:
- 207-325-9
- EC Name:
- Trifluoro(tetrahydrofuran)boron
- Cas Number:
- 462-34-0
- Molecular formula:
- C4H8BF3O
- IUPAC Name:
- trifluoro(oxolan-1-ium-1-yl)boranuide
- Details on test material:
- Name of the test substance used in the study report: Borfluorid-Tetrahydrofuran
Batch number 5/93
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animal weight: 150 - 300 g
Individual identification of the rats using cage cards and group identification by tail marking.
The animals were housed in fully air-conditioned rooms with 20 - 24°C for temperature and 30 - 70% for relative humidity. The day/night rhythm was 12 h dark and 12 h light. The rats were singly hold in stainless steel wire mesh cages without beding. A standard diet and tap water were offered ad libitum per day.
The acclimatization period was at least 1 week. The animals were given no feed at least 16 hours before administration; water was available ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Doses:
- 200 mg/kg and 2000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days (200 mg/kg); 0 days (2000 mg/kg)
- Frequency of observations and weighing: shortly before application, weekly thereafter and at the end of the study.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Mortality:
- 200 mg/kg 0/3; 2000 mg/kg 3/3
- Clinical signs:
- other: 200 mg/kg group: impaired general state and dyspnea. 2000 mg/kg group: poor general state, dyspnoea, apathy, abdominal position, staggering, ataxia, paresis, cyanosis
- Gross pathology:
- Animals that died: hemorrhage in the mucosa of the stomach and substance discoloration of the contents in the small intestines.
No abnormalities were found in sacrificed animals.
Applicant's summary and conclusion
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