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Ecotoxicological information

Short-term toxicity to fish

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Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Experimental data of test chemicals
Justification for type of information:
Data for the test chemical is from peer reviewed journal
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two short term toxicity study of fish for the test chemical :
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
other: 1) Oncorhynchus mykiss 2) Ictalurus punctatus
Details on test organisms:
1st: - Common name: Rainbow trout
2: - Common name: Channel Catfish
- Weight: 1.3 g
Test type:
static
Water media type:
freshwater
Total exposure duration:
96 h
Reference substance (positive control):
no
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
2.8 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: 1st study
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
2.09 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: 2nd study
Validity criteria fulfilled:
no
Conclusions:
1: Based on the mortality rate of fish Oncorhynchus mykiss by the chemical exposure for 96 hrs, the LC50 was observed at 2.8 mg/L.
2: Based on the mortality rate of fish Oncorhynchus mykiss by the chemical exposure for 96 hrs, the LC50 was observed at 2.09 mg/L.
Executive summary:

Data available for the test chemicals has been reviewed to determine the short term toxicity of the test chemical on the mortality of fish.The studies are as mentioned below:

In the first study test material was subjected to evaluate its acute toxicity effect on Oncorhynchus mykiss. Aim of this study was determine the effect of test chemical on the mortality of fish Oncorhynchus mykiss. Test conducted under the static system for 96 hrs. Based on the mortality rate of fish Oncorhynchus mykiss by the chemical exposure for 96 hrs, the LC50 was observed at 2.8 mg/L.

Above results were supported by the second experimental study from authoritative database. Aim of this study was determine the effect of test chemical on the mortality of fish Ictalurus punctatus (Channel Catfish). Test conducted under the static system for 96 hrs. 1.3 g channel catfish were used in the study. Based on the mortality rate of fish Ictalurus punctatus(Channel Catfish) by the chemical exposure for 96 hrs, the LC50 was observed at 2.09 mg/L.

Based on the above results, chemical can be consider to be toxic, however the obtained median letal concentration is very much higher than the solubility of the test chemical. Thus considering water solubility and toxicity values test chemical can be categorised into not classified category.

Description of key information

1: Based on the mortality rate of fish Oncorhynchus mykiss by the chemical exposure for 96 hrs, the LC50 was observed at 2.8 mg/L.

2: Based on the mortality rate of fish Oncorhynchus mykiss by the chemical exposure for 96 hrs, the LC50 was observed at 2.09 mg/L.

Based on the above results, chemical can be consider to be toxic, however the obtained median letal concentration is very much higher than the solubility of the test chemical. Thus considering water solubility and toxicity values test chemical can be categorised into not classified category

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
2.8 mg/L

Additional information

Data available for the test chemical including structually and functionally similar read across chemical has been reviewed to determine the short term toxicity of the test chemical on the mortality of fish.The studies are as mentioned below:

In the first study test material was subjected to evaluate its acute toxicity effect onOncorhynchus mykiss. Aim of this study was determine the effect of test chemical on the mortality of fish Oncorhynchus mykiss. Test conducted under the static system for 96 hrs. Based on the mortality rate of fish Oncorhynchus mykiss by the chemical exposure for 96 hrs, the LC50 was observed at 2.8 mg/L.

Above results were supported by the second experimental study from authoritative database.Aim of this study was determine the effect of test chemical on the mortality of fish Ictalurus punctatus (Channel Catfish). Test conducted under the static system for 96 hrs. 1.3 g channel catfish were used in the study. Based on the mortality rate of fish Ictalurus punctatus(Channel Catfish) by the chemical exposure for 96 hrs, the LC50 was observed at 2.09 mg/L.

Based on the above results, chemical can be consider to be toxic, however the obtained median letal concentration is very much higher than the solubility of the test chemical. Thus considering water solubility and toxicity values test chemical can be categorised into not classified category