[1,1'-Biphenyl]-2-carbonitrile, 4'-methyl-

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Year:

1996

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

422-310-9

EC Name:

-

Cas Number:

114772-53-1

Molecular formula:

C14H11N

IUPAC Name:

4'-methyl-[1,1'-biphenyl]-2-carbonitrile

Test animals

Species:

rat

Strain:

Sprague-Dawley

Administration / exposure

Vehicle:

other: Solution aqueuse de methylcellulose

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

< 2 000 mg/kg bw

Mortality:

Male: 500mg/kg bw, Number of animals:5; Number of deaths: 0
Male: 1000mg/kg bw, Number of animals:5; Number of deaths: 1
Male: 200mg/kg bw, Number of animals:5; Number of deaths: 4
Female: 1000mg/kg bw, Number of animals:5; Number of deaths: 0

Clinical signs:

other: Sings of toxicity related to dose levels: A 500mg/kg chez les males, prostration au jour 1

Gross pathology:

Effects o organs:
A la dose de 1000mg/kg, poumons rouge fonce, meteorisation intestinale et point rouges sur le thymus.
A 2000mg/kg, presence de sang seche sur le museau, poumons rouge, meteorisation stomacale, congestion intestinale et foie pale.

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU