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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
422-310-9
EC Name:
-
Cas Number:
114772-53-1
Molecular formula:
C14H11N
IUPAC Name:
4'-methyl-[1,1'-biphenyl]-2-carbonitrile

Test animals

Species:
rat
Strain:
Sprague-Dawley

Administration / exposure

Vehicle:
other: Solution aqueuse de methylcellulose

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
< 2 000 mg/kg bw
Mortality:
Male: 500mg/kg bw, Number of animals:5; Number of deaths: 0
Male: 1000mg/kg bw, Number of animals:5; Number of deaths: 1
Male: 200mg/kg bw, Number of animals:5; Number of deaths: 4
Female: 1000mg/kg bw, Number of animals:5; Number of deaths: 0
Clinical signs:
Sings of toxicity related to dose levels:
A 500mg/kg chez les males, prostration au jour 1
Gross pathology:
Effects o organs:
A la dose de 1000mg/kg, poumons rouge fonce, meteorisation intestinale et point rouges sur le thymus.
A 2000mg/kg, presence de sang seche sur le museau, poumons rouge, meteorisation stomacale, congestion intestinale et foie pale.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU

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