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EC number: 279-791-1 | CAS number: 81646-13-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.6 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 30
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 17.6 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- No data on toxicity of the submission substance after long-term inhalation available.
- AF for dose response relationship:
- 1
- Justification:
- ECHA Guidance
- AF for differences in duration of exposure:
- 3
- Justification:
- Longer-term repeated dose studies for analogue substances do not indicate lower NOAELs for similar effects.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- inhalation route, ECHA Guidance
- AF for other interspecies differences:
- 1
- Justification:
- substance is considered to exert its effects directly, without the need for metabolism, through its surfactant properties which are unlikely to differ between species
- AF for intraspecies differences:
- 5
- Justification:
- ECHA Guidance
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Guidance
- AF for remaining uncertainties:
- 2
- Justification:
- route-to-route extrapolation (oral to inhalation), ECHA Guidance
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 60
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 200 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- No adequate data for dermal exposure pathway. Oral abs. rat approx. 10%, dermal abs. humans <0.5%: 20 times lower
- AF for dose response relationship:
- 1
- Justification:
- ECHA Guidance
- AF for differences in duration of exposure:
- 3
- Justification:
- Longer-term repeated dose studies for analogue substances do not indicate lower NOAELs for similar effects.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- ECHA Guidance
- AF for other interspecies differences:
- 1
- Justification:
- substance is considered to exert its effects through its surfactant properties which are unlikely to differ between species
- AF for intraspecies differences:
- 5
- Justification:
- ECHA Guidance
- AF for the quality of the whole database:
- 1
- Justification:
- ECHA Guidance
- AF for remaining uncertainties:
- 1
- Justification:
- ECHA Guidance
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- medium hazard (no threshold derived)
Additional information - workers
DNEL long-term exposure - systemic effects - dermal
No data on toxicity of the submission substance after long-term dermal exposure are available. Due to its low water solubility and highly ionic nature the substance will not be readily absorbed from the gastrointestinal tract or skin (see e.g. European Commission,Sanco/222/2000 rev. 7, 19 March 2004:Guidance Document on Dermal Absorption). As worst case consideration a DNEL "long-term dermal exposure - systemic effects" can be derived by route-to-route extrapolation of data after long-term oral exposure to the closely related substance Quaternary ammonium compounds, C20-22-alkyltrimethyl, chlorides, for which in a 28-day subacute oral study with rats a NOAEL of 10 mg/kg bw/d has been derived. This NOAEL is regarded as starting point for the derivation of the worker DNEL. Based on its ionic nature and the low water solubility it can be assumed that the dermal absorption and the oral absorption are small. Based on toxicokinetic data for structurally very similar substances, it can be assumed that the oral absorption in rats is approx. 10% and dermal absorption is <0.5%. Therefore, the corrected dermal NOAEL is obtained by multiplying the NOAEL with 20, resulting in 200 mg/kg/day.
An allometric scaling factor of 4 is applied for interspecies extrapolation. A factor 1 was used for remaining interspecies differences, because the substance is considered to exert its effects through its surfactant properties which are unlikely to differ between species.
A time extrapolation factor of 3 was used to account for possible differences in subacute to chronic exposure duration. This factor is lower than the default factor of 6 for subacute to chronic extrapolation, because several supporting long-term (subchronic or chronic) toxicity studies with analogue substances are available, which show that NOAELs for similar effects exerted by the analogue substances are similar or even higher after prolonged exposure.
In the absence of any substance specific data a default factor of 5 is used for intraspecies extrapolation is applied, based on ECHA Guidance document on Information Requirements and CSA, R.8.
The resulting overall assessment factor is 60 (4 x 3 x 5). Based on these data a worker DNEL "long-term dermal exposure - systemic effects" of 3 mg/kg bw/day is derived for the submission substance.
DNEL long-term exposure - systemic effects - inhalation
No data on toxicity of the submission substance after long-term inhalation exposure are available. As worst case consideration a worker DNEL "long-term inhalation exposure - systemic effects" can be derived by route-to-route extrapolation of data after long-term oral exposure to the closely related substance Quaternary ammonium compounds, C20-22-alkyltrimethyl, chlorides, for which in a 28-day subacute oral study with rats a NOAEL of 10 mg/kg bw/d has been derived. This NOAEL is regarded as starting point for the derivation of the worker DNEL "long-term inhalation exposure - systemic effects". Based on its ionic nature and the low water solubility it is assumed that the oral absorption and the inhalation absorption are small and that absorption is similar for both routes of exposure and between species. As no experimental data are available, for the remaining uncertainty the default factor of 2 for oral-to-inhalation extrapolation will be applied. The corrected inhalatory NOAEC is obtained by multiplying the NOAEL with 1/0.38 m³/kg/day * 6.7 m³ / 10 m³ as 17.6 mg/m³.
A factor 1 was used for remaining interspecies differences, because the substance is considered to exert its effects directly, without the need for metabolism, through its surfactant properties which are unlikely to differ between species.
A time extrapolation factor of 3 was used to account for possible differences in subacute to chronic exposure duration. This factor is lower than the default factor of 6 for subacute to chronic extrapolation, because several supporting long-term (subchronic or chronic) toxicity studies with analogue substances are available, which show that NOAELs for similar effects exerted by the analogue substances are similar or even higher after prolonged exposure.
In the absence of any substance specific data a default factor of 5 is used for intraspecies extrapolation, based on ECHA Guidance document on Information Requirements and CSA R.8.
The resulting overall assessment factor is 30 (2 x 1 x 3 x 5). Based on these data a DNEL "long-term inhalation exposure “systemic effects" of 0.6 mg/m³ is derived for the subsmission substance.
Inhalation of the substance is not considered a potential route of exposure based on use patterns and the low vapour pressure and considering technical protection measures employed (partly use of closed systems, local exhaust ventilation).
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
With regard to consumer exposure, the submission substance is used only in cosmetic products. Therefore, derivation of DNELs, assessment of exposure and risk characterization are not required (ECHA guidance R8).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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