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Description of key information

No experimental toxicokinetic study is available on Ethoxylated bisphenol A dimethacrylate. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties.
Based on the toxicological data and the physicochemical properties, a low absorption of the substance is expected by oral or dermal route and by inhalation.

Key value for chemical safety assessment

Additional information

No experimental toxicokinetic study is available on Ethoxylated bisphenol A dimethacrylate. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, including:

-Molecular weight: [452 -584] g/mol for 89% of the reaction mass

-Water solubility: 1.89 mg/L 

-Partition coefficient Log Kow: full range = [3.43 -5.62] ; [5.30 -5.62] for 73.3% of the reaction mass

-Vapour pressure: 0.117 10^-6 Pa (20°C)

 

ABSORPTION

The value of log Kow (> 5) and the low water solubility are in the range suggestive of low absorption from the gastro-intestinal tract subsequent to oral ingestion. Indeed the absorption of highly lipophilic substances may be limited by the inability of such substances to dissolve into GI fluids.

With low water solubility, a high value of log Kow and a molecular mass near to 500 g/mol, dermal absorption is anticipated to be low (50%). Moreover, the acrylates are known to bind to skin components, and this binding decreases their dermal absorption.

Based on the very low value of the vapour pressure, Ethoxylated bisphenol A diacrylate is not a volatile substance. With the low water solubility,no absorption by inhalation is expected for this substance.

 

DISTRIBUTION and METABOLISM

The molecule is lipophilic (log Kow >5), it is likely to distribute into cells and the intracellular concentration may be higher than extracellular concentration particularly in fatty tissues.

No specific data is available on the metabolism of Ethoxylated bisphenol A dimethacrylate.

 

ELIMINATION

Due to the low water solubility and a moderate molecular mass (near to 500 g/mol), the excretion of Ethoxylated bisphenol A dimethacrylate in the urines is not expected. An excretion via bile and faeces is possible.