Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Currently viewing:

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: results sufficiently stated

Data source

Reference
Reference Type:
publication
Title:
Maximum permissible concentration of p-chlorophenyl isocyanate in factory air
Author:
Frolova IN
Year:
1966
Bibliographic source:
Hygiene & Sanitation 31 (7-9), 481-483 (Engl. translation)

Materials and methods

Study type:
study with volunteers
Endpoint addressed:
eye irritation
Principles of method if other than guideline:
threshold of irritating effects on eyes (no further data) was determined
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chlorophenyl isocyanate
EC Number:
203-176-9
EC Name:
4-chlorophenyl isocyanate
Cas Number:
104-12-1
Molecular formula:
C7H4ClNO
IUPAC Name:
1-chloro-4-isocyanatobenzene
Details on test material:
TS-Freetext:
4-Chlorophenyl isocyanate, no purity specified

Method

Subjects:
human volunteers (no further data)
Route of exposure:
ocular
Reason of exposure:
intentional
Exposure assessment:
not specified

Results and discussion

Clinical signs:
subjects complained of unpleasant sensations in their eyes

Any other information on results incl. tables

RM-Freetext:
In the case of human subjects the threshold of irritating action was 0.0008 mg/l for a one-minute exposure (no further
information from the English translation of the Russian

publication)

Applicant's summary and conclusion

Executive summary:

In the case of human subjects the threshold of irritating action was 0.0008 mg/l for a one-minute exposure.

The subjects complained of unpleasant sensations in their eyes.