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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

acute oral toxicity: LD50 = 138 mg/kg bw (rat, female); LD50 = 335 mg/kg bw (rat, male); other studies found a LD50 > 2000 mg/kg bw (rat, male); LD50 = 6000 mg/kg bw (rat, m+f) or LD50 = 4750 mg/kg bw (rat, m+f)
acute inhalation toxicity: LC50 = ca.113 mg/m³ (rat, female); LC50 = 113-272 mg/m³(rat, male)
acute dermal toxicity: LD50 > 2000 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
138 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
113 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

Justification for classification or non-classification

For the acute oral toxicity T, R25 is justified as a result of the LD50 = 138 mg/kg bw

For the acute inhalation toxicity T+, R26 is justified as a result of the LC50 = 113 mg/m³ air

In addition, several studies reported respiration irritational effects. Therefore R 37 is applicable