Registration Dossier
Registration Dossier
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EC number: 203-176-9 | CAS number: 104-12-1
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: number of animals too small
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
- Principles of method if other than guideline:
- 2 ml of a 20 % solution of the test substance in methylene chloride was sprayed in a 400 l vessel in which 1 rabbit, 1 guinea pig, 2 rats and 4 mice were placed. after 1 hour the same amount was sprayed again into the vessel. after 2 hours the animals were removed from the vessel. the test was repeated on 5 consecutive days.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chlorophenyl isocyanate
- EC Number:
- 203-176-9
- EC Name:
- 4-chlorophenyl isocyanate
- Cas Number:
- 104-12-1
- Molecular formula:
- C7H4ClNO
- IUPAC Name:
- 1-chloro-4-isocyanatobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: p-chlorophenyl isocyanate, purity: >99%
Constituent 1
Test animals
- Species:
- other: 1 rabbit, 1 guinea pig, 2 rats and 4 mice
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: methylene chloride
- Remarks on MMAD:
- MMAD / GSD: no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 5 days
- Frequency of treatment:
- 2 hours once a day
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 mg/l
Basis:
nominal conc.
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- Post-exposure period: no data
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Remarks on result:
- not determinable
- Remarks:
- no NOAEC identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
all animals died within 14 days. The animals had strong mucosal
irritations and showed elaborated breathing.
Applicant's summary and conclusion
- Executive summary:
method: 4 ml of a 20 % solution of the test substance in methylen chloride was sprayed in a 400 l vessel in which 1 rabbit, 1 guinea pig, 2 rats and 4 mice were placed. after 1 hour the same amount was sprayed again into the vessel. after 2 hours the animals were removed from the vessel. the test was repeated on 5 consecutive days.
result. all animals died within 14 days
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