Perfluamine

Long-term toxicity to fish

Administrative data

Endpoint:

fish life cycle toxicity

Data waiving:

exposure considerations

Justification for data waiving:

other:

Justification for type of information:

We propose waiving of long-term toxicity to fish of perfluorotripropyl amines (PTPA, CAS# 338-83-0) in accordance with section 3 of Annex XI of the REACH Regulation (regarding substance-tailored exposure-driven testing). PTPA is a liquid at room temperature with low water solubility (0.381 µg/L), vapor pressure (3.87 mm Hg at 20°C), and a high Henry's Law constant range (read across from analogous compounds of similar water solubility) of 3400 - 4020 atm·m³/mol. Releases are expected to be atmospheric emissions based upon its intended uses. Fugitive emissions may occur at transfer points. During routine use, there is no anticipated release to aquatic systems. Based on its physicochemical qualities, PTPA will not partition to water or sediment but will remain in the atmosphere when released from industrial applications. A long-term presence of PTPA would not be maintained in the aquatic compartment and aquatic organisms would not be subject to a chronic exposure. The vapor pressure, low water solubility and the extremely high Henry’s law constant combine to move PTPA from any aquatic compartment into the atmosphere. Therefore, this compound will remain in the atmosphere when released from industrial applications. Exposure modeling was conducted using EUSES v.2.1.2 in order to generate environmental exposure data to evaluate the significance of exposure. Predicted environmental concentrations (PECs) in the freshwater and marine compartments were 6.41E-06 mg/L and 6.49E-07 mg/L, respectively. Worst-case predicted no-effect concentrations (PNECs) in freshwater and marine compartments are 1.192E-04 mg/L and 1.19E-05 mg/L. The resulting RCRs for the freshwater and marine water aquatic compartments, 0.0538 and 0.0545, are clearly < 1, indicating that exposures are always well below the derived PNEC. It should be noted that the PNECs are based on maximum attainable test substance concentration; no toxicity was observed in reliable tests. The PNECs are thus more conservative than is typical. There is no need for further information and testing.