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A sensory irritation study with MITC was carried out to provide data on the irritating properties of MITC and to discriminate between sensory (nasal) irritation and pulmonary irritation in rats (Arts, 1993). From the results of the present study, it was concluded that the RD50 value of methyl isothiocyanate was 93 mg/m3 as determined according to Alarie (1973) and 95 ± 8 mg/m3 according to Bos et al.(1992). These RD50 values were not affected by the inhibitory effects if the solvent ethanol.