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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary literature

Data source

Reference
Reference Type:
publication
Title:
Summary of toxicity data on methyl isothiocyanate (MITC)
Author:
Anonymous
Year:
1990
Bibliographic source:
Nippon Noyaku Gakkai (J. Pesticide Sci.), 15(2), 297-304.

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl isothiocyanate
EC Number:
209-132-5
EC Name:
Methyl isothiocyanate
Cas Number:
556-61-6
Molecular formula:
C2H3NS
IUPAC Name:
isothiocyanatomethane
Details on test material:
no data

Test animals

Species:
other: rat and mouse
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Details on exposure:
no
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no
Statistics:
no data

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LC50
Effect level:
60 mg/kg bw
Remarks on result:
other: RATS
Sex:
female
Dose descriptor:
LC50
Effect level:
59 mg/kg bw
Remarks on result:
other: RATS
Sex:
male
Dose descriptor:
LC50
Effect level:
75 mg/kg bw
Remarks on result:
other: MICE
Sex:
female
Dose descriptor:
LC50
Effect level:
89 mg/kg bw
Remarks on result:
other: MICE
Mortality:
LD50 were determined.
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion