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Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics in vitro / ex vivo
Adequacy of study:
key study
Objective of study:
other: Assessment of toxicokinetic behaviour
Conclusions:
In conclusion, no bioaccumulation potential based on study results is concluded.

Description of key information

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

Effects following repeat oral exposure confirm that absorption takes place and adaptive changes indicated by effects on enzymes would suggest that a certain level of metabolism is taking place. The substance quickly loses its identity in water and it is probable that exposure to animals is to the breakdown products. The breakdown products are water soluble and are thought unlikely to accumulate. Changes in the kidney in the repeat dose study indicate that the substance or its metabolites passes through the kidney, but there is no evidence as to whether renal excretion takes place.