Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-022-8 | CAS number: 6915-15-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Old study conforming to standards aceptable at the time. Published in a peer-reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Inactive Malic Acid as a Food Acidulant
- Author:
- Weiss JM, Downs CR and Corson HP
- Year:
- 1 923
- Bibliographic source:
- Industrial and Engineering Chemistry 15(6): 628-630, 1923
- Reference Type:
- publication
- Title:
- The nephropathic action of the dicarboxylic acids and their derivatives I: Tartaric, malic and succinic acids
- Author:
- Rose WC
- Year:
- 1 924
- Bibliographic source:
- J. Pharmacol Exp Ther 24(2): 123-146, 1924
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The date of the study (published in 1924) precedes current test methods. Acute toxicity studies are based on standard methods although this study will not have investigated additional endpoint other than mortality.
- GLP compliance:
- no
- Remarks:
- The study pre-dates the establishment of GLP guidelines and regulations
Test material
- Reference substance name:
- Hydroxy succinic acid
- IUPAC Name:
- Hydroxy succinic acid
- Reference substance name:
- DL-malic acid
- EC Number:
- 210-514-9
- EC Name:
- DL-malic acid
- Cas Number:
- 617-48-1
- Molecular formula:
- C4H6O5
- IUPAC Name:
- 2-hydroxybutanedioic acid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
Administration / exposure
- Route of administration:
- subcutaneous
- Doses:
- Subcutaneous injection of 1.5, 3 and 5 g dl-mailic acid on successive days after omitting 1 day
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The l(+) isomer had a negigible effect on rate or renal output of phenolsulphonphthalein and no effect on non-protein nitrogen and chlorine levels in the blood.
The dl isomer produced a reduction in the excretion rate and total output of the phenolsulphonphthalein dye and a rise in non-protein nitrogen.
Neither isomer altered blood creatinine levels (Rose, 1924).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
