Registration Dossier
Registration Dossier
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EC number: 205-154-4 | CAS number: 134-72-5
Endpoint summary
Administrative data
Description of key information
The test substance is not irritating or corrosive to the skin and eye determined in an OECD 404 and 405 guideline study, respectively.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation / corrosion
The potential to cause acute dermal irritation or corrosion was assessed in a OECD 404 guideline study (BASF 1986). The intact skin of three Vienna White rabbits was exposed by a single topical application of an amount of 0.5 g of the test substance for 4 hours using a patch of 2.5 cm x 2.5 cm covered with a semiocclusive dressing. After removal of the patch, the application area was washed off. The cutaneous reactions were assessed immediately after removal of the patch and approximately 24, 48, 72 hours after removal. No effects were observed. It was concluded that the test substance was not irritating to the skin.
Eye irritation
The potential to cause damage to the conjunctiva, iris and cornea was assessed in an OECD 405 guideline study in which 3 Vienna white rabbits were subjected to a single ocular application of 0.1 mL of the test substance on day 0 (BASF 1986). The mean score (24 to 72 hours) for irritation was calculated to be 0, 0, and 0.7 for corneal opacity, 0, 0, and 0 for iris, 0, 0, and 1 for chemosis, and 1, 1, and 1 for conjunctivae redness, for animal 1, 2, and 3 respectively. Findings were reversible within 72 hours after application. It was concluded that the test substance was not irritating to the eye.
Justification for selection of skin irritation / corrosion endpoint:
One skin irritation / corrosion study is available. This study is adequate for covering this endpoint.
Justification for selection of eye irritation endpoint:
One eye irritation study is available. This study is adequate for covering this endpoint.
Justification for classification or non-classification
Based on the fact that no effects were observed after skin exposure and very limited effects were observed after ocular application, classification for skin irritation / corrosion and eye irritation is not warranted in accordance with Directive 67/548/EEC (DSD) and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
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