Reaction mass of ethanol and propan-2-ol

Long-term toxicity to fish

Administrative data

Endpoint:

long-term toxicity to fish

Type of information:

(Q)SAR

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: QSAR regarded as reliable.

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Data source

Reference

Reference Type:

other: QSAR model

Title:

Ecological Structure Activity Relationships (ECOSAR) model) v1.00a

Author:

US EPA

Year:

2009

Bibliographic source:

http://www.epa.gov/oppt/newchems/tools/21ecosar.htm

Materials and methods

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

QSAR model

Test material

Test material information

Constituent 1

Reference substance name:

Ethanol

EC Number:

200-578-6

EC Name:

Ethanol

Cas Number:

64-17-5

Molecular formula:

C2H6O

IUPAC Name:

ethanol

Test organisms

Test organisms (species):

no data

Study design

Test type:

not specified

Water media type:

freshwater

Total exposure duration:

30 d

Results and discussion

Effect concentrations

Duration:

30 d

Dose descriptor:

other: ChV (equivalent to a NOEC)

Effect conc.:

245 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

mortality

Any other information on results incl. tables

This result compares to the prediction from the model that the chronic toxicity threshold value for daphnid is 92mg/l and that for green algae 56mg/l. This is also consistent with the acute toxicity results predicted by the model of 2178mg/l (96hr, fish), 1117mg/l (48hr daphnid), 209mg/l (96hr algae). The acute toxicity data is highly consistent with the measured data and this gives confidence to the conclusion that fish are not likely to be the most sensitive species in a chronic toxicity study.