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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP study, no guideline followed; not single exposure but 9

Data source

Reference Type:
The subacute inhalation toxicity of 109 industrial chemicals
Bibliographic source:
Brlt . J. industr . Med., 1970, 27, 1-1 8

Materials and methods

Test guideline
no guideline followed
Principles of method if other than guideline:
Rats were exposed to the test substance for 6h/d nine times; in this study the effect of several chemicals following inhalation was tested
GLP compliance:
Test type:
other: repeated inhalation

Test material

Constituent 1
Chemical structure
Reference substance name:
Triboron trimethyl hexaoxide
EC Number:
EC Name:
Triboron trimethyl hexaoxide
Cas Number:
Molecular formula:
Details on test material:
The samples submitted by ICI Divisions were prepared in either the Research Department or an experimental plant, or were taken from full-scale production

Test animals

other: Alderley Park specific-pathogen-free rats
Details on test animals or test system and environmental conditions:
No details in environmental condictions given

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Details on inhalation exposure:
Atmospheres were continuously generated and passed through the exposure chamber. The air used fot the atmospheres was filtered, dried to a
relative humidity of less than 10%, and supplied at a line pressure of 1 atm. A nearly saturated vapour obtained by passing air through a liquid contained in a bubbler with a sintered glass air-distributor disc . The volume of the liquid was usually 10-20 ml and, if the size of the sample available permitted, it was replaced daily . Unless otherwise stated, the bubbler was maintained in a water-bath at room temperature, about 20°C.
The nearly saturated concentration was estimated by weighing the sample before and after the day's run, and relating the weight loss to the volume of air passing . This concentration, expressed in milligrammes per litre, was converted to parts per million on the assumption that the sample was pure .
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Remarks on duration:
9 exposures
Saturated atmosphere
No. of animals per sex per dose:
3 M/ 4F
Details on study design:
Rats were weighed each morning, and their conditions and behaviour were recorded throughout the exposure period . Urine was collected overnight after the last exposure day for biochemical tests . The animals were left overnight with food and drink . On the following day the rats were anaesthetized with halothane and partially exsanguinated by heart puncture for haematological tests . After a gross examination of the organs, the lungs were inflated with formol-saline and immersed in the same fixative . The following organs were also taken for microscopical examination after fixation
in formol-corrosive : lungs, liver, kidneys, spleen, and adrenals ; and occasionally heart, jejunum, ileum, and thymus.

Results and discussion

Effect levels
Dose descriptor:
Effect level:
> 3 mg/L air
no mortalities described
Clinical signs:
other: slight lethargy
Body weight:
no data
Gross pathology:
Organs normal

Applicant's summary and conclusion