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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was conducted according to the O.E.C.D. test guideline 121 with GLP compliance.

Data source

Reference Type:
study report
Report date:

Materials and methods

Test guideline
according to guideline
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
soil/sewage sludge

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-epoxypropyl neodecanoate
EC Number:
EC Name:
2,3-epoxypropyl neodecanoate
Cas Number:
Molecular formula:
Oxiran-2-ylmethyl 2-ethyl-2,5-dimethylhexanoate
Constituent 2
Reference substance name:
Neodecanoic acid, oxiranylmethyl ester
Neodecanoic acid, oxiranylmethyl ester
Test material form:
other: Colorless liquid at room temperature.
Details on test material:
As per IUCLID5 Sections 1.1. 1.2. 1.4. and 4.1. for 2,3-epoxypropyl neodecanoate, REACH Registration: 01-2119431597-33-0000.
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
As per IUCLID5 Sections 1.1. 1.2. 1.4. and 4.1. for 2,3-epoxypropyl neodecanoate, REACH Registration: 01-2119431597-33-0000.

Study design

Test temperature:

HPLC method

Details on study design: HPLC method:
Test item (0. 1074 g) was diluted to 100 ml with methanol to give a concentration of 1 .07 gm/L. The dead time was determined by measuring the retention time of formamide (purity* 99.94%, 738 mg/L solution in mobile phase). Solutions of reference standards:Acetanilide, Phenol, Atrazine, Isoproturon, Triadimeno, Linuron, Naphthalene, Endosulfan-diol, Fenthion, Phenanthrene, Diclofop-methyl and DDT were prepared in methanol.

The test sample, dead time and reference standard solutions were injected in duplicate using the following HPLC parameters:
HPLC System - Agilent Technologies 1200 incorporating workstation, Column - Luna CN 5 t (1 50 x 4.6 mm id) and Column temperature - 30 °C, Mobile phas - Methanol:water (55 :45 v/v) and pH ofmobile phase - 6.5, Flow-rate - 1.0 mL/min, Injection volume - 10 u1, Uv detector wavelength - 210 nm.

A calibration curve was constructed from the retention time data of the dead time and reference standard solutions. The capacity factors k’ for the reference standards were calculated.

Results and discussion

Adsorption coefficient
log Koc
ca. 2.16
Remarks on result:
other: Temperature as ambient.

Results: HPLC method

Details on results (HPLC method):
Injection Retention Time (mins) Capacity Factor (k) Log10 k Mean Log10 Ko Adsorption Coefficient
1 3.212 0.620 -0.208
2 3.163 0.595 -0.225 2.16 143

Applicant's summary and conclusion

Validity criteria fulfilled:
The mean Log Koc was 2.16 suggesting a low potential of the test substance to adsorb to soil and sediment.
Executive summary:

The structural analog, 2,3-epoxypropyl neodecanoate was tested for Adsorption/Disorption by O.E.C.D. test guideline 121 HPLC method. The mean Log Koc was determined to be 2.16 suggesting a low potential of the test substance and Neononanoic acid glycidyl ester to adsorb to soil and sediment.