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Diss Factsheets
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EC number: 271-234-0 | CAS number: 68526-85-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles, pre-GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Test material was applied by skin contact once daily for a total of 10 applications with a one-day rest period between the first and second applications, and a two day rest period between the third and fourth and eight and ninth applications.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Alcohols, C7-9-iso-, C8-rich
- EC Number:
- 271-231-4
- EC Name:
- Alcohols, C7-9-iso-, C8-rich
- Cas Number:
- 68526-83-0
- Molecular formula:
- CnH2n+1OH (n = 7 to 9)
- IUPAC Name:
- Branched alcohols, C7-9, C8 rich
- Details on test material:
- - Name of test material (as cited in study report): MRD-59-12
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 1.6-2.5 kg
- Acclimation period: 5 d
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- TEST SITE
- Area of exposure: Back and/or abdominal skin
- % coverage: 10% for 0.5 ml/kg dose, 40% for the 2.5 ml/kg dose
- Type of wrap if used: Gauze and plastic sleeve
- Time intervals for shavings or clippings: Frequent intervals
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 or 2.5 ml/kg
- Concentration (if solution): 100%
- Constant volume or concentration used: no - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 18-24 hours estimated exposure time.
- Frequency of treatment:
- Test material was applied by skin contact once daily for a total of 10 applications with a one-day rest period between the first and second applications, and a two day rest period between the third and fourth and eight and ninth applications.
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0.5
Basis:
other: ml/kg/application
- Remarks:
- Doses / Concentrations:
2.5
Basis:
other: ml/kg/application
- No. of animals per sex per dose:
- 2 Male, 2 Female
- Details on study design:
- - Undiluted control and test material were applied to intact skin of the animals once daily for a total of 10 applications with a 1 day rest period between the first and second applications, and a 2 day rest period between the third and fourth and eighth and ninth applications.
- Positive control:
- Isopropyl alcohol
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS:
- Time schedule: Daily
DERMAL IRRITATION (if dermal study): Yes
- Time schedule for examinations: daily
HAEMATOLOGY: Yes
- Time schedule for collection of blood: Initially and 24 hours following the final application
- Parameters checked: total erythrocyte count, total and differential leukocyte counts, hematocrit determination
URINALYSIS: Yes
- Time schedule for collection of urine: Initially and 24 hours following the final application
- Parameters checked: Complete urine analysis. - Sacrifice and pathology:
- GROSS PATHOLOGY:
- 48 hours following the tenth application the animals were sacrificed by intravenous air embolism.
- From each animal, samples of brain, thyroid, lung, heart, liver, kidney, adrenals, skin, and bone marrow. - Statistics:
- No data analyzed
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Dermal irritation:
- effects observed, treatment-related
- Mortality:
- no mortality observed
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- no effects observed
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
- Details on results:
- CLINICAL SIGNS AND MORTALITY
- No mortality from exposure
BODY WEIGHT AND WEIGHT GAIN
- Final weight of each animal was increased over the initial value.
HAEMATOLOGY
- General improvement in hematocrit and total erythrocyte during the course of the study
- Slight shift in the differential count noted in the high dose group
- Terminal increase in segmented neutrophils count in the high dose group
URINALYSIS
- Unremarkable
GROSS PATHOLOGY
- Unremarkable
Effect levels
open allclose all
- Dose descriptor:
- other: skin irritation
- Effect level:
- >= 0.5 other: ml/kg
- Sex:
- male/female
- Basis for effect level:
- other: Moderate erythema, slight or moderate edema, and slight to marked atonia and desquamation.
- Dose descriptor:
- NOAEL
- Effect level:
- > 2.5 other: ml/kg
- Sex:
- male/female
- Basis for effect level:
- other: No adverse systemic effects reported.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Repeated applications of isooctanol at 0.5 or 2.5 ml/kg of body weight produced moderate or marked degree of dermal irritation. The irritation was characterized by slight or moderate erythema, slight or moderate edema, and slight to marked atonia and desquamation.
- Executive summary:
In this study, male and female rabbits were subjected to a repeated dose of either 0.5 or 2.5 ml/kg body weight isooctanol. Undiluted control and test material were applied to intact skin of the animals once daily for a total of 10 applications with a 1 day rest period between the first and second applications, and a 2 day rest period between the third and fourth and eighth and ninth applications. Repeated applications of isooctanol produced moderate or marked degree of dermal irritation. The irritation was characterized by slight or moderate erythema, slight or moderate edema, and slight to marked atonia and desquamation. In addition, two of the low level animals showed slight necrosis, and all of the high level animals showed fissuring and a coriaceous condition of the skin. No adverse systemic effects were noted even at the highest dose of 2.5 ml/kg.
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