Registration Dossier
Registration Dossier
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EC number: 205-533-4 | CAS number: 142-30-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Before OECD Guideline 404 was establisched in 1982, skin irritation was tested using an internal BASF method. White Vienna rabbits were treated for 1, 5 and 15 minutes and 20 hours using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with 80% aqueous solution of the test substance. In addition, skin tissue from the ear was tested by wrapping the ear. After application time, the skin was washed. The animals were observed 8 days and skin changes were recorded.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,5-dimethylhexyne-2,5-diol
- EC Number:
- 205-533-4
- EC Name:
- 2,5-dimethylhexyne-2,5-diol
- Cas Number:
- 142-30-3
- Molecular formula:
- C8H14O2
- IUPAC Name:
- 2,5-dimethylhex-3-yne-2,5-diol
- Details on test material:
- - Name of test material (as cited in study report): Dimethylhexindiol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- An application site of 2.5x2.5 was covered with a 80% aqueous solution
- Duration of treatment / exposure:
- - back: 1, 5, 15 minutes, and 20 h
- ear: 20 h - Observation period:
- 8 days
- Details on study design:
- The skin was washed to remove the test substance.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 3
- Irritant / corrosive response data:
- - No effects were observed in animals exposed for 1, 5 or 15 minutes on the back.
- 24 hours after exposure questionable redness was observed in animals exposed on the back for 20 hours. These effects were no longer present 8 days after exposure.
- 24 hours after exposure slight redness was observed in the animals exposed for 20 h on the ear.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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