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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 202-347-5 | CAS number: 94-60-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: older study; non GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dimethyl cyclohexane-1,4-dicarboxylate
- EC Number:
- 202-347-5
- EC Name:
- Dimethyl cyclohexane-1,4-dicarboxylate
- Cas Number:
- 94-60-0
- Molecular formula:
- C10H16O4
- IUPAC Name:
- 1,4-dimethyl cyclohexane-1,4-dicarboxylate
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Duration of exposure:
- 6 h
- Concentrations:
- 0.97 mg/L (117 ppm); 2.91 mg/L (355 ppm)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- airflow through compartment was 2L/min at either room temperature (117 ppm) or 100 deg. C (355 ppm)
Results and discussion
- Preliminary study:
- Atmospheric concentration of 2.91 mg/L of DMCD for 6 hours caused no symptoms or adverse effects
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 2.91 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 6 h
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Atmospheric concentration of 2.91 mg/L of DMCD for 6 hours caused no symptoms or adverse effects
- Executive summary:
In an acute inhalation experiment, 3 rats were exposed to a chamber concentration of 0.97 mg/L (117 ppm) for 6 hours, and a separate group of 3 rats were exposed to a chamber concentration of 2.91 mg/L (355 ppm) for 6 hours. At the end of the exposure period, there were no symptoms or adverse effects observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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