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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study

Data source

Reference
Reference Type:
publication
Title:
Biological fate of sulfur mustard. Urinary excretion profiles of hydrolysis products and beta-lyase metabolites of sulfur mustard after cutaneous application in rats.
Author:
Black RM, Hambrook JL, Howells DJ, Read RW
Year:
1992
Bibliographic source:
J Anal Toxicol 16: 79-84

Materials and methods

Type of study / information:
Thiodiglycol as a metabolite
Principles of method if other than guideline:
Thiodiglycol as a metabolite of sulfur mustard in rats

Test material

Constituent 1
Chemical structure
Reference substance name:
Thiodiglycol
EC Number:
203-874-3
EC Name:
Thiodiglycol
Cas Number:
111-48-8
Molecular formula:
C4H10O2S
IUPAC Name:
2-[(2-hydroxyethyl)sulfanyl]ethan-1-ol
Details on test material:
no further data

Results and discussion

Any other information on results incl. tables

Concentrations of thiodiglycol detected increased up to 10 -fold after treatment of the urine with hydrochloric acid, presumably because of the excretion fo acide-labile esters of thiodiglycol. Free thiodiglycol excreted over 8 days accounted for 0.3% of the applied dose of sulfur mustard (free thiodiglycol plus esterified thiodiglycol 1 -1.5% of the applied dose).

Applicant's summary and conclusion

Conclusions:
Thiodiglycol is a metabolite of sulfur mustard in rats
Executive summary:

Thiodiglycol is a metabolite of sulfur mustard in rats