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Registration Dossier
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EC number: 203-874-3 | CAS number: 111-48-8
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
Data source
Reference
- Reference Type:
- publication
- Title:
- Biological fate of sulfur mustard. Urinary excretion profiles of hydrolysis products and beta-lyase metabolites of sulfur mustard after cutaneous application in rats.
- Author:
- Black RM, Hambrook JL, Howells DJ, Read RW
- Year:
- 1 992
- Bibliographic source:
- J Anal Toxicol 16: 79-84
Materials and methods
- Type of study / information:
- Thiodiglycol as a metabolite
- Principles of method if other than guideline:
- Thiodiglycol as a metabolite of sulfur mustard in rats
Test material
- Reference substance name:
- Thiodiglycol
- EC Number:
- 203-874-3
- EC Name:
- Thiodiglycol
- Cas Number:
- 111-48-8
- Molecular formula:
- C4H10O2S
- IUPAC Name:
- 2-[(2-hydroxyethyl)sulfanyl]ethan-1-ol
- Details on test material:
- no further data
Constituent 1
Results and discussion
Any other information on results incl. tables
Concentrations of thiodiglycol detected increased up to 10 -fold after treatment of the urine with hydrochloric acid, presumably because of the excretion fo acide-labile esters of thiodiglycol. Free thiodiglycol excreted over 8 days accounted for 0.3% of the applied dose of sulfur mustard (free thiodiglycol plus esterified thiodiglycol 1 -1.5% of the applied dose).
Applicant's summary and conclusion
- Conclusions:
- Thiodiglycol is a metabolite of sulfur mustard in rats
- Executive summary:
Thiodiglycol is a metabolite of sulfur mustard in rats
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