Registration Dossier

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The following information is available for the short-term acute toxicity to fish endpoint tested on the structural analogue DBTO:
Steger-Hartmann T. & Wendt B. (1998) Acute toxicity of di-n-butyltin oxide (ZK 26385) to the Zebra fish Danio rerio. Testing laboratory: Schering AG, Experimentelle Toxikologie. Report no.: IC19. Owner company: Schering AG Report date: 1998-12-11. LOEC determined as 3.10 mg/l.
Nagase H. et al. (1991) Structure-activity relationships for organotin compounds on the red killifish Oryzias latipes. Applied Organometallic Chemistry 5: 91-97. The short term LC50 is 0.839 mg/L.
The Steger-Hartmann and Wendt study has been rated as 1 under the Klimisch scoring system and so is considered sufficient to address this endpoint. The Nagase et al study is a QSAR study but is insufficient to address the endpoint and has been rated as 4 under the Klimisch scoring system.

Key value for chemical safety assessment

Additional information

The following data are all available to the registrant for the structural analogue DBTO.

Steger-Hartmann T and Wendt B (1998), the key study, was performed in compliance with GLP and according to the guideline OECD 203. As such, the study was assigned a reliability score of 1 and considered adequate for assessment. Ten Zebra fish were used in each test solution of di-n-butyltin oxide. No mortality was observed in the control. One fish was found dead after 72 hours of exposure in the saturated solution of di-n-butyltin oxide. During exposure, the fish showed signs of abnormal behaviour nearly at all time points. 10% mortality was observed, therefore di-n-butyltin oxide is of low acute toxicity to fish up to 3.10 mg/l (maximum of solubility, determined on the basis of TOC analysis).

 

Nagase H et al (1991) was provided as supporting information. The study was performed to the guideline OECD 203 in order to examine parameters for a QSAR of 29 organotins, however, areas of the methodology were lacking in detail and therefore it was not possible to accurately assign a reliability score. The LC50 for di-n-butyltin oxide was 0.839 mg/L, determined with red killifish Oryzias latipes. This paper studied the QSAR of 29 organotin compounds. They concluded that the physicochemical and topological parameters used as independent variables were not good descriptors for estimating the LC50 value.