Sodium 5-oxo-L-prolinate

Water solubility

Description of key information

Water solubility = 613 ± 68 g/L,  EU Method A. 6, OECD 105, Sárvári 2013b.

Key value for chemical safety assessment

Water solubility:

613 g/L

at the temperature of:

20 °C

Additional information

The key study (Sárvári, 2013b) was performed under GLP conditions and in accordance with standardised guidelines. The study was assigned a reliability score of 1 in line with the principles for assessing data quality as defined by Klimisch (1997). Under the conditions of the study, the solubility of the test material was determined to be 613 ± 68 g/L at 20 °C ± 1° and is considered to be very soluble.

The supporting study (Butler, 2008) was performed using information on the read across substance, sodium 5-oxo-DL-prolinate, which is a racemic mixture of the D- and L- isomeric forms of the substance. Read-across is considered to be suitable based on the structural similarities between the read across substance (sodium 5-oxo-DL-prolinate) and the substance to be registered (sodium 5-oxo-L-prolinate), which is the L- isomer only. As such the difference in isomeric forms of the substance is unlikely to affect the physico-chemical properties. The study was conducted under GLP conditions and in accordance with standardised guidelines. The study was assigned a reliability score of 2 in line with the principles for assessing data quality as defined by Klimisch (1997). Under the conditions of the study, the water solubility of the test material was determined to be in the range of 84.2 to 86.6 % w/w at 20.0 ± 0.5 ºC, and is considered to be very soluble. The results of this study are in good agreement with the results presented in the key study.