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Description of key information

Acute oral toxicity, rat:  LD50 = 2423 mg/kg (BASF AG 1981)
Acute dermal toxicity, rabbit: LD50 > 2500 - < 5000 mg/kg (Moreno 1973)

Key value for chemical safety assessment

Additional information

Acute oral toxicity

In the chosen key study, i.e. an acute oral toxicity test with Sprague-Dawley rats similar to OECD Guideline 401, LD50 values of 2872, 2150 and 2423 mg/kg bw were calculated for male, female and males/females combined, respectively (BASF AG 1981).

Acute dermal toxicity

In the key study for acute dermal toxicity in rabbits, beeing available as short summary from a secondary source, an LD50 > 2500 - <5000 mg/kg bw has been reported (Moreno 1973). No mortalities and clinical signs were reported in groups of 5 rabbits at 2500 mg/kg bw, while 3 from 5 rabbits died at 5000 mg/kg. In addition, the dermal LD50of the structurally similar citral is also greater than 2000 mg/kg bw (BASF 1978). During a 14-day post-observation period no mortality or signs of intoxication occurred besides local irritating effects.

Acute inhalation toxicity

During an inhalation hazard test (BASF 1981; performed according to Smyth et al., 1962) with a 7-hr exposure of rats to a vapour atmosphere enriched with citronellal, no mortalities occurred. Test animals showed clinical signs of respiratory irritation. As a rough estimate, the concentration in the atmosphere was calculated to be 1.39 mg/L air based on the loss of test substance during the exposure. Due to the limited experimental design, this acute inhalation toxicity study is solely considered as supportive evidence for the absence of acute inhalative toxicity of citronellal.

Justification for classification or non-classification

The present data on acute toxicity do not fulfill the criteria laid down in 67/548/EEC and CLP, and therefore, a non-classification is warranted. However citronellal has to be classified as acute toxic – oral (category 5) and acute toxic – dermal (category 5) according to UN-GHS.