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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

The lethal concentration (LC50) value of difluoroacetic acid in aquatic invertebrate (Daphnia magna) in a 48 hr study on the basis of mortality effect was found to be 235.793 mg/L. Based on this prediction it can be infered that the target chemical is non toxic to aquatic environment.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
235.793 mg/L

Additional information

No. of studies reviewed for short – term toxicity to fish from reliable sources having Klimisch rating 2 and 4.

The summary of the results are presented below


Sr. No.


Effect values

Basis for effects






235.79 mg/L


48 hrs

Daphnia magna

Predicted data from QSAR



21767.93 mg/L


48 hrs

Daphnia magna

Predicted data from ECOSAR


By applying weight of evidence approach to the test substance difluoroacetic acid, the endpoint value was found to LC50 = 235.79 mg/L & 21767.93 mg/L in a 48 hrs. to 48 hrs. study on the basis of mortality effect. The BCF value of difluoroacetic acid reported was not >= 500 as well as the substance was found to be rapidly degradable