Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 485-320-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Acute toxicity:
Oral (OECD 423), rat: LD50 ≥ 5000 mg/kg bw (LD50 cut-off value)
Dermal (OECD 402), rabbit: LD50 > 2000 mg/kg bw (limit test)
Inhalation (OECD 403), rat: LD50 > 3513 mg/m³ (limit test)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 3 513 mg/m³
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
The acute oral toxicity study was performed in accordance with OECD 423 (Schüngel, 2005). The the substance formulated in tap water with 2% Cremophor EL was administered by gavage to rats in a dose of 2000 mg/kg bw. There were no deaths or signs of toxicity during the study. Gross examination of organs and tissues at necropsy did not reveal any abnormalities. According to OECD 423, the LD50 cut-off value of the test substance was ≥ 5000 mg/kg bw.
According to OECD 402, 2000 mg/kg bw of the test substance was dermally applied to the intact skin of rats (Schüngel, 2005). The test substance was placed on a wet gauze patch and applied to the skin for 24 h under semi-occlusive conditions. After the exposure period, the gauze patch was removed and the treated skin was rinsed and dried. There were no deaths or signs of toxicity during the study. Gross examination of organs and tissues at necropsy did not reveal any abnormalities. The LD50 of the test substance was > 2000 mg/kg bw.
The acute inhalation toxicity of the test substance on rats was conducted in accordance with OECD 403 (Pauluhn, 2004). The rats were nose-only exposed to a mean solid aerosol concentration (powder) of 3513 mg/m³. The aerosol generated was respirable to the rats (MMAD 3.2 µm, GSD 1.8). The maximum achievable concentration of 3513 mg/m³ did not cause mortality. Nonspecific clinical signs were observed in some females without indication of a treatment-relationship. There were no effects on body weight development. Gross examination at necropsy did not reveal any abnormalities. The LC50 of the test substance was > 3513 mg/m³.
Justification for classification or non-classification
The available data on acute toxicity (oral, inhalation and dermal) of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.