Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-544-9 | CAS number: 108-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Two Daphnia magna acute toxicity tests were conducted with 1-nitropropane according to the OECD 202 daphid acute toxicity guideline. The most recent test (2009) was conducted under GLP while the older test was a non-GLP study. In addition, a QSAR value for daphnids was generated using the USEPA ECOSAR v1.00 model as part of EPISuite v4.
The key study for aquatic invertebrate toxicity is the most recent daphnid acute toxicity test. This test was conducted under GLP, using flow-through conditions to maintain test concentrations due to the volatile potential for the chemical. Analytical verification of test solutions was conducted and demonstrated that test concentrations were on target and remained stable for the duration of the exposure. The results are calculated based on mean measured concentrations. The 48-hour EC50 was 380 mg 1-nitropropane/L.
The supporting study determined a similar value with a 24-hour EC50 of 258 mg 1-nitropropane/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 380 mg/L
Additional information
The key study for aquatic invertebrate acute toxicity is the most recent test. This test was conducted under GLP, using sealed-vessels with zero-headspace to minimize loss of test material due to the volatile potential for the chemical. Analytical verification of test solutions was conducted and demonstrated that test concentrations were on target and remained stable for the duration of the exposure. The results are calculated based on arithmetic mean measured concentrations. The 48-hour EC50 was 380 mg/L.
The report for the earlier study did not provide adequate detail on test conditions or test methods to be considered a key study. This study was also only conducted for 24 hours rather than the current requirement of 48 hours. However, at the time this study was conducted, the OECD 202 guideline requirement was a 24-hour exposure. The report was inconclusive as to whether the exposures were conducted in sealed test vessels and or whether exposure concentrations were maintained over the 24-hour exposure period. Three exposures were conducted and a mean 24-hour EC50 value of 258 mg/L was reported. The reported results from this test were somewhat consistent with the results for the recent test (24-hour EC50 values of 258 and 696 mg/L, respectively). The 24-hour EC50 values are within approximately a factor of two, indicating a consistent response.
The ECOSAR LC50 value was 281 mg/L, which is similar to the experimentally derived EC50 values.
These results indicate that 1-nitropropane is not dangerous to freshwater aquatic invertebrates.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
