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EC number: 203-544-9 | CAS number: 108-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 7.1 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 18
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 30.5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 3
- Modified dose descriptor starting point:
- NOAEC
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3.6 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 18
- Dose descriptor:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 21.3 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 3
- Dose descriptor starting point:
- NOAEC
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 83 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 72
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 500 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 12
- Modified dose descriptor starting point:
- NOAEL
Local effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
Workers - Hazard for the eyes
Additional information - workers
The major use of 1 -nitropropane is as a chemical intermediate for the manufacture of pharmaceutical products, pesticides, surfactants and resins. Other uses include propellant fuel, gasoline additives, and solvents. The predominant route of occupational exposure for 1 -nitropropane is inhalation. Products containing 1 -nitropropane are not widely used by consumers.
Dermal DNELs:
Dermal DNELs for acute short-term local effects and long-term exposure local effects were not derived for 1-nitropropane. No dermal studies examining the systemic toxicity of 1-nitropropane were found. Instead a route-to-route extrapolation is used from a repeat dose oral study. No classification or labeling is required for 1-nitropropane since it is not irritating to the skin and the LD50> 2000. Pharmacokinetic studies in monkeys indicate that 1-nitropropane is poorly absorbed from the skin (< 0.5% in 12 hrs). Also, 1 -nitropropane is not readily absorbed through the skin and volatilizes quickly from the skin's surface. Therefore, no acute dermal DNELs for local effects are necessary for this compound.
The following DNELs were derived using ECETOX guidance document entitled, “Guidance on Assessment Factors to Derive DNELs” Final draft. March 17th2010
WORKER DNELs
Dermal DNEL: Acute/Short-Term worker exposure systemic effects
A NOAEL from a oral 28 day study in rats was used to derive a dermal DNEL acute/short term exposure systemic effects.
Dose Modification:
Percutaneous absorption from non-human primate = 0.5%
Therefore: 30 mg/kg/day ÷0.005 = 6000 mg/kg/day
Assessment factors:
Allometric scaling from rat to human = 4
Remaining Difference = 1
Intraspecies adjustment factor for worker population = 3
Exposure Duration (Subacute study) = N/A
Worker dermal DNEL Acute/Short-Term Exposure Systemic Effects = 6000 mg/kg/day/4*3 =500 mg/kg/day
Inhalation DNEL: Acute/Short-term worker exposure systemic effects
The NOEC of 50 ppm (182 mg/m3) was taken from a sub-acute inhalation study to derive an inhalation DNEL general population.
Time Adjustment for 6 hr/8 hr day exposure = (6 h/d)/(8 h/d)
Adjustment for respiration rate = 6.7 m3/10m3
Allometric Scaling factor (rat) = 1 (Not applicable when setting an inhalation DNEL from an inhalation animal study)
Remaining Differences = 1
Subacute to Acute = N/A
Intraspecies variation for the general population = 3
inhalation DNELworker population = (182 mg/m3)(6/8)(6.7/10)(1/3) =30.5 mg/m3
Inhalation DNEL: Acute/short-term worker exposures: local effects
The NOEC of 25 ppm (91 mg/m3) was taken from a sub-acute inhalation study
Time adjustment for 6 hr/day exposure = (6 hr/day)/(8h/day)
Adjustment for respiration rate (8 hr) = (6.7 m3)/(10 m3)
Time Adjustment for 5 day/week worker exposure = (7 days/week)/(5 days/week)
Allometric Scaling factor (rat) = 1 (not appropriate for local effects)
Remaining Differences = 1
Sub acute to Acute = N/A
Intraspecies variation for the worker population = 3
Inhalation DNEL worker = (91 mg/m3)(6/8)(6.7/10)(7/5)(1/3) =21.3 mg/m3
Dermal DNEL: Long Term worker exposures: systemic Effects.
WORKER: Dermal DNEL for Chronic/Long-Term Exposure Systemic Effects
A NOAEL from a oral 28 day study in rats was used to derive a dermal DNEL chronic /long-term exposure systemic effects.
Dose Modification:
Percutaneous absorption from non-human primate = 0.5%
Therefore: 30 mg/kg/day ÷.005 = 6000 mg/kg/day
Assessment factors:
Allometric scaling from rat to human = 4
Remaining Difference = 1
Intraspecies adjustment factor for worker population = 3
Exposure Duration (From Subacute study to Chronic) = 6
Worker dermal DNEL Acute/Short-Term Exposure Systemic Effects = 6000 mg/kg/day/4*3*6 =83 mg/kg/day
Inhalation DNEL: Long-term exposure systemic effects.
The NOEC of 50 ppm (182 mg/m3) was taken from a sub-acute inhalation study.
Time Adjustment for 6 hr/day exposure = (6 h/d)/(8 h/d)
Adjustment for respiration rate (8 hr) = (6.7 m3)/(10 m3)
Time Adjustment for 5 day/week worker exposure = (7 days/week)/(5 days/week)
Allometric Scaling factor (rat) = 1 (not applicable when setting an inhalation DNEL from an inhalation animal study)
Remaining Differences = 1
Subacute to chronic = 6
Intraspecies variation for the worker population = 3
inhalation DNELworker = (182 mg/m3)(6/8)(6.7/10)(7/5)(1/6)(1/3) =7.1 mg/m3
Inhalation DNEL: Long-term Exposure local effects:
The NOEC of 25 ppm (91 mg/m3) was taken from a sub-acute inhalation study
Time adjustment for 6 hr/day exposure = (6 hr/day)/(8h/day)
Adjustment for respiration rate (8 hr) = (6.7 m3)/(10 m3)
Time Adjustment for 5 day/week worker exposure = (7 days/week)/(5 days/week)
Allometric Scaling factor (rat) = 1 (not appropriate for local effects)
Remaining Differences = 1
Sub acute to Chronic = 6
Intraspecies variation for the worker population = 3
Inhalation DNEL worker = (91 mg/m3)(6/8)(6.7/10)(7/5)(1/6)(1/3) =3.6 mg/m3
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 30
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 9.1 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 5
- Modified dose descriptor starting point:
- NOAEC
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.76 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 30
- Dose descriptor:
- NOAEC
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.6 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 5
- Dose descriptor starting point:
- NOAEC
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 50 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 120
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 300 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 20
- Modified dose descriptor starting point:
- NOAEL
Local effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.25 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 120
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 20
- Modified dose descriptor starting point:
- NOAEL
General Population - Hazard for the eyes
Additional information - General Population
CONSUMER DNELs
Dermal DNELs:Acute short-term local effects and long term exposure local effects. were not derived for 1-nitropropane. No dermal studies examining the systemic toxicity of 1-nitropropane were found. No classification or labeling is required for 1-nitropropane since it is not irritating to the skin and the LD50> 2000. Pharmacokinetic studies in monkeys indicate that 1-nitropropane is poorly absorbed from the skin (< 0.5% in 12 hrs). Also, 1 -nitropropane is not readily absorbed through the skin and volatilizes quickly from the skin's surface. Therefore, no acute dermal DNELs for local effects are necessary for this compound.
Dermal DNEL: Acute/Short-Term general population exposure systemic effects
A NOAEL from an oral 28 day study in rats was used to derive a dermal DNEL acute/short term exposure systemic effects.
Dose Modification:
Percutaneous absorption from non-human primate = 0.5%
Therefore: 30 mg/kg/day ÷0.005 = 6000 mg/kg/day
Assessment factors:
Allometric scaling from rat to human = 4
Remaining Difference = 1
Intraspecies adjustment factor for general population = 5
Exposure Duration (Subacute study) = N/A
General Population: dermal DNEL Acute/Short-Term Exposure Systemic Effects = 6000 mg/kg/day/4*5 =300 mg/kg/day
Inhalation DNEL: Acute/Short-term exposure systemic effects
The NOEC of 50 ppm (182 mg/m3) was taken from a sub-acute inhalation study to derive an inhalation DNEL general population.
Time Adjustment for 6 hr/day exposure = (6 h/d)/(24 h/d)
Allometric Scaling factor (rat) = 1 (Not applicable when setting an inhalation DNEL from an inhalation animal study)
Remaining Differences = 1
Subacute to acute = N/A
Intraspecies variation for the general population = 5
inhalation DNELgeneral population = (182 mg/m3)(6/24)(1/5) =9.1 mg/m3
Oral DNEL: Acute/Short-term exposure systemic effects
The NOEL of 30 mg/kg/day was taken from a subacute oral study to derive an oral DNEL general population acute short term exposure systemic effects.
Allometric Scaling factor (rat) = 4
Remaining differences = 1
Intraspecies differences for general population = 5
Subacute to Acute = N/A
oral DNEL general population = (30 mg/kg/day)(1/4)(1/5) =1.5 mg/kg/day
Inhalation DNEL: Acute/short-term exposures: local effects
The NOEC of 25 ppm (91 mg/m3) was taken from a 28 day sub-acute inhalation study
Time adjustment for 6 hr/day exposure = (6 hr/day)/(24h/day)
Allometric Scaling factor (rat) = 1 (not appropriate for local effects)
Remaining Differences = 1
Subacute to Acute = N/A
Intraspecies variation for the general population = 5
inhalation DNEL general population = (91 mg/m3)(6/24)(1/5) =4.55 mg/m3
Dermal DNEL: Long Term general population exposures: systemic effects.
A NOAEL from a oral 28 day study in rats was used to derive a dermal DNEL chronic /long-term exposure systemic effects.
Dose Modification:
Percutaneous absorption from non-human primate = 0.5%
Therefore: 30 mg/kg/day ÷.005 = 6000 mg/kg/day
Assessment factors:
Allometric scaling from rat to human = 4
Remaining Difference = 1
Intraspecies adjustment factor for general population = 5
Exposure Duration (From Subacute study to Chronic) = 6
General Population: dermal DNEL Acute/Short-Term Exposure Systemic Effects = 6000 mg/kg/day/4*5*6 =50 mg/kg/day
Inhalation DNEL: Long-term exposure systemic effects.
The NOEC of 50 ppm (182 mg/m3) was taken from a sub-acute inhalation study.
Time Adjustment for 6 hr/day exposure = (6 h/d)/(24 h/d)
Allometric Scaling factor (rat) = 1 (Not applicable when setting an inhalation DNEL from an inhalation animal study)
Remaining Differences = 1
Subacute to chronic = 6
Intraspecies variation for the general population = 5
inhalation DNELgeneral population = (182 mg/m3)(6/24)(1/6)(1/5) =1.5 mg/m3
Oral DNEL: Long-term, Exposure systemic effects
The NOEL of 30 mg/kg/day was taken from a subacute oral study
Allometric Scaling factor (rat) = 4
Remaining differences = 1
Intraspecies differences for general population = 5
Subacute to Chronic study = 6
oral DNEL gen pop = (30 mg/kg/day)(1/4)(1/6)(1/5) =0.25 mg/kg/day
Inhalation DNEL: Long-term Exposure local effects
The NOEC of 25 ppm (91 mg/m3) was taken from a 28 day sub-acute inhalation study
Time adjustment for 6 hr/day exposure = (6 hr/day)/(24h/day)
Allometric Scaling factor (rat) = 1 (not appropriate for local effects)
Remaining Differences = 1
Subacute to Chronic = 6
Intraspecies variation for the general population = 5
inhalation DNEL general population = (91 mg/m3)(6/24)(1/6)(1/5) =0.76 mg/m3
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