Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-544-9 | CAS number: 108-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, comparable to a guideline study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- comparable to guideline study
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1-nitropropane
- EC Number:
- 203-544-9
- EC Name:
- 1-nitropropane
- Cas Number:
- 108-03-2
- Molecular formula:
- C3H7NO2
- IUPAC Name:
- 1-nitropropane
- Details on test material:
- The analytical report submitted with the sample indicated that the purity of the test material was 96.12%. The test material also contained (by weight) 2.44% 2-nitropropane, 0.64% 1-nitro-2-methyl propane, 0.42% 2-nitrobutane, 0.35% 2-nitro-2-methyl propane, and 0.013% water. Other minor impurities were not listed.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- Body weights: 3.4 +/- 0.3 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped- intract and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- The test was conducted in six albino rabbits weighing 3.4 +/- 0.3 kg. The skin from the back area of each animal was clipped free of hair. The skin site left of the middorsal line on each rabbit was left intact and the skin on the right side was abraded at 2 sites with a blunt hypodermic needle. The abrasions went through the stratum corneum but did not disturb the derma or produce bleeding. A total of 4 sites (2 intact and 2 abraded) were tested per animal.
A 0.5 ml sample of test material was applied to each site and covered with a moistened gauze pad. The entire trunk was then wrapped with a rubberized, impervious cloth and a flexible stainless steel wire screen held in place by tape. The dressings were removed after 24 hours and the treated skin sites were gently cleaned. The skin reactions were scored immediately (24 hr) and 48 hours later (for a total of 72 hours).
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 and 48 hour average score
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Maximum score is 4 for erythema and edema.
- Irritant / corrosive response data:
- All erythema and edema scores at 24 and 72 hours were 0. The material was not irritating.
- Other effects:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified as toxic
- Remarks:
- Criteria used for interpretation of results: other: EU GHS
- Conclusions:
- All erythema and edema scores at 24 and 72 hours were 0. The material was not irritating.
- Executive summary:
None
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
