Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Intradermal sensitization test in the guinea pig and is comparable to a guideline study and well detailed. None of the 10 guinea pigs in the study show a positve response when challenges with 1 -nitropropane.

Migrated from Short description of key information:
One key study was identified assessing the skin sensitization potential of 1-nitropropane in the guinea pig. The protocol was comparable to a guideline study.

Justification for classification or non-classification

None of the animals that were challenge with 1 -nitropropane after the induction phase showed any evidence of skin sensitization. Therefore, 1 -nitropropane is not sensitizing in the guinea pig and is not classifiable.