Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
carcinogenicity
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2010
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
In silico prediction. DEREK is a knowledge-based expert system designed to apply structure-activity relationships to compounds for which little or no data exists and hence to aid in the assessment of their potential toxicity. The DEREK knowledge base contains a large number of rules that associate a chemical structure with one or more toxicity end points. When a structural alert is identified a reasoning programme assigns a probability to the expression of toxicity by the test compound.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(m-chlorophenyl)piperazine
EC Number:
229-654-7
EC Name:
1-(m-chlorophenyl)piperazine
Cas Number:
6640-24-0
Molecular formula:
C10H13ClN2
IUPAC Name:
1-(3-chlorophenyl)piperazine

Results and discussion

Effect levels

Dose descriptor:
other: alert
Sex:
not specified
Basis for effect level:
other: No alert
Remarks on result:
other: Effect type: carcinogenicity (migrated information)

Any other information on results incl. tables

DEREK evaluation showed no alert for carcinogenicity.

Applicant's summary and conclusion

Conclusions:
DEREK evaluation showed no alert for carcinogenicity.