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EC number: 485-350-6 | CAS number: 405095-33-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August - October 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- This study has been performed in compliance with GLP in Switzerland, Procedures and Principles, March 1986, issued by the Swiss federal Department of the Interior and the Intercantonal Office for the Control of Medicaments.
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 240 mg CaCO3/l
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 15.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 13.1-17.9 mg/L;
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 27.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 22.4-31.4 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Remarks:
- Criteria: In the control not more than 10% of the daphnids should have been immobilised. The dissolved oxygen concentration at the end of the test should be > or equal 3 mg/l in control and test vessels.
- Conclusions:
- EC50,48h calculated: 15.7 mg/l
NOEC48h: 10 mg/l
EC0,48h: 10.0 mg/l
EC100,48h: 32.0 mg/l - Executive summary:
Purpose of this study was to determine the acute toxicity (EC50 (48h)) of CA 1139 A on Daphnia (Daphnia magna Straus 1820).
The test was conducted according the OECD guideline 202.
20 Daphnia were used per concentration and control. 4 replicates were conducted of 5 daphnia each.
The duration of the test was 48h. Nominal test concentrations were: 5.8, 10, 18, 32, 58 and 100 mg test substance/l.
Calculated results were as follow (values are based on nominal concentrations):
EC50,48h calculated: 15.7 mg/l
NOEC48h: 10 mg/l
EC0,48h: 10.0 mg/l
EC100,48h: 32.0 mg/l
Reference
Immobilization (Initial number of daphnia = 20/test conc.)
Conc. nominal mg/l |
Immobilization after 24 h |
Immobilization after 48 h |
||||||||||
in vessel: |
total |
in vessel: |
total |
|||||||||
1 |
2 |
3 |
4 |
number |
% |
1 |
2 |
3 |
4 |
number |
% |
|
Blank |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5.8 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
10 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
18 |
0 |
0 |
0 |
0 |
0 |
0 |
5 |
3 |
3 |
5 |
16 |
80 |
32 |
3 |
5 |
4 |
5 |
17 |
85 |
5 |
5 |
5 |
5 |
20 |
100 |
58 |
5 |
5 |
5 |
5 |
20 |
100 |
5 |
5 |
5 |
5 |
20 |
100 |
100 |
5 |
5 |
5 |
5 |
20 |
100 |
5 |
5 |
5 |
5 |
20 |
100 |
Description of key information
Purpose of this study was to determine the acute toxicity (EC50 (48h)) of CA 1139 A on
Daphnia (Daphnia magna Straus 1820).
The test was conducted according the OECD guideline 202.
20 Daphnia were used per concentration and control. 4 replicates were
conducted of 5 daphnia each.
The duration of the test was 48h. Nominal test concentrations were: 5.8,
10, 18, 32, 58 and 100 mg test substance/l.
Calculated results were as follow (values are based on nominal
concentrations):
EC50,48h calculated: 15.7 mg/l
NOEC48h: 10 mg/l
EC0,48h: 10.0 mg/l
EC100,48h: 32.0 mg/l
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 15.7 mg/L
Additional information
Guideline Test Type |
Species |
Conclusion |
Reference |
Reliability
|
OECD 202 |
Daphnia magna (Straus 1820) |
EC50(48 h) calculated: 15.7 mg/l NOEC (48 h): 10 mg/l EC0(48 h): 10 mg/l |
Grade R., Ciba-Geigy, 1992 |
Reliable without restrictions |
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