5-chloro-α,α,α-trifluoro-2-nitrotoluene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP and Guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method B.1 (Acute Toxicity (Oral))

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

yes (incl. QA statement)

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

5-chloro-α,α,α-trifluoro-2-nitrotoluene

EC Number:

204-280-7

EC Name:

5-chloro-α,α,α-trifluoro-2-nitrotoluene

Cas Number:

118-83-2

Molecular formula:

C7H3ClF3NO2

IUPAC Name:

4-Chloro-1-nitro-2-(trifluoromethyl)benzene

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: oleum sesami

Doses:

500, 630, 900, 1250, 1600 mg/kg BW

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

554 mg/kg bw

Based on:

test mat.

95% CL:

>= 422 - <= 641

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria