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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Animals were treated with a single dose and observed during 14 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Isodecyl acrylate
EC Number:
215-542-5
EC Name:
Isodecyl acrylate
Cas Number:
1330-61-6
Molecular formula:
C13H24O2
IUPAC Name:
2-methyloctyl prop-2-enoate
Test material form:
other: liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Mellon Institute
- Age at study initiation: 3 - 4 weeks
- Weight at study initiation: 90 - 120 g
- Diet (e.g. ad libitum): Rockland diets
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
undiluted substance
Doses:
20, 10 and 5 ml/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
no
Statistics:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
9 486 mg/kg bw
Remarks on result:
other: original data: 10.7 ml/kg
Remarks:
LD50 (mg/kg) = LD50 (ml/kg) x density x 1000 = 10.7 x 0.8866 x 1000 = 9486 mg/kg
Mortality:
20.0 ml/kg: 5/5 animals died on day 0, 1 ,1 ,3 and 5
10.0 ml/kg: 2/5 animals died on day 2 and 3
5.0 ml/kg: 0/5; all animals survived
Clinical signs:
other: Prostrate and heavy breathing within one hour; sluggish at 24 hours, slightly sluggish 5 min after dose.
Gross pathology:
Congestion throught thee lungs and the abdominal viscera in the victims; livers mottled.
Other findings:
no

Any other information on results incl. tables

Dosage; ml/kg

Dead / Dosed

Days to Death

Weight Change

Signs and/or Sympthoms

20.0

5/5

0,1,1,3,5

-

Prostrate and heavy breathing within one hour; sluggish at 24 hours, slightly sluggish 5 min after dose.

10.0

2/5

2,3

67 to 73

5.0

0/5

-

68 to 91

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Based on the results on this acute study, an oral LD50 of 9486 mg/kg was calculated in rats.
Executive summary:

In this study, rats were treated orally with isodecyl acrylate a single dose of 5, 10 or 20 ml/kg.

This study was conducted as a range-finding test according to the method described by Smyth HF Jr. and Carpenter CP (1948).

All animals treated with 20 ml/kg died in the 5 days after administration. Two animals died at the dose of 10 ml/kg on day 2 and 3.

A LD50 value of approx. 9486 mg/kg bw (10,7 ml/kg) was determined.