Isodecyl acrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Animals were treated with a single dose and observed during 14 days.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Isodecyl acrylate

EC Number:

215-542-5

EC Name:

Isodecyl acrylate

Cas Number:

1330-61-6

Molecular formula:

C13H24O2

IUPAC Name:

2-methyloctyl prop-2-enoate

Test material form:

other: liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Mellon Institute
- Age at study initiation: 3 - 4 weeks
- Weight at study initiation: 90 - 120 g
- Diet (e.g. ad libitum): Rockland diets
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

undiluted substance

Doses:

20, 10 and 5 ml/kg

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

no

Statistics:

no

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

9 486 mg/kg bw

Remarks on result:

other: original data: 10.7 ml/kg

Remarks:

LD50 (mg/kg) = LD50 (ml/kg) x density x 1000 = 10.7 x 0.8866 x 1000 = 9486 mg/kg

Mortality:

20.0 ml/kg: 5/5 animals died on day 0, 1 ,1 ,3 and 5
10.0 ml/kg: 2/5 animals died on day 2 and 3
5.0 ml/kg: 0/5; all animals survived

Clinical signs:

other: Prostrate and heavy breathing within one hour; sluggish at 24 hours, slightly sluggish 5 min after dose.

Gross pathology:

Congestion throught thee lungs and the abdominal viscera in the victims; livers mottled.

Other findings:

no

Any other information on results incl. tables

Dosage; ml/kg	Dead / Dosed	Days to Death	Weight Change	Signs and/or Sympthoms
20.0	5/5	0,1,1,3,5	-	Prostrate and heavy breathing within one hour; sluggish at 24 hours, slightly sluggish 5 min after dose.
10.0	2/5	2,3	67 to 73
5.0	0/5	-	68 to 91

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Based on the results on this acute study, an oral LD50 of 9486 mg/kg was calculated in rats.

Executive summary:

In this study, rats were treated orally with isodecyl acrylate a single dose of 5, 10 or 20 ml/kg.

This study was conducted as a range-finding test according to the method described by Smyth HF Jr. and Carpenter CP (1948).

All animals treated with 20 ml/kg died in the 5 days after administration. Two animals died at the dose of 10 ml/kg on day 2 and 3.

A LD50 value of approx. 9486 mg/kg bw (10,7 ml/kg) was determined.