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EC number: 215-542-5 | CAS number: 1330-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Inhalation Hazard Test was performed.
- GLP compliance:
- no
- Test type:
- other: Inhalation Hazard Test
- Limit test:
- yes
Test material
- Reference substance name:
- Isodecyl acrylate
- EC Number:
- 215-542-5
- EC Name:
- Isodecyl acrylate
- Cas Number:
- 1330-61-6
- Molecular formula:
- C13H24O2
- IUPAC Name:
- 2-methyloctyl prop-2-enoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth Farms-Elias (Albino)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- no
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Concentrated vapor, generated at approx. 21 °C by passind dried air at the rate of 2.5 liters/minute through a fritted glass disc immersed to a depth of al least one inch in 50 ml of isodecyl acrylate. The exposure period was eight-hours in a 9-liter chamber.
- Duration of exposure:
- 8 h
- Concentrations:
- saturated vapour concentration
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- other: Inhalation risk test
- Effect level:
- ca. 333 mg/m³ air
- Exp. duration:
- 8 h
- Remarks on result:
- other: No mortality occurred
- Mortality:
- No animals died.
- Clinical signs:
- other: All Animals appeared to be normal when removed from the inhalation chamber.
- Body weight:
- All animals gained weight during the subsequent 14-day observation period.
- Gross pathology:
- no
- Other findings:
- no
Any other information on results incl. tables
Single Inhalation by a Group of Female Allbino T´Rats of Concentrated Vapor Generated at approx. 21 °C.
Rat Number |
Date and duration of Inhalation |
Conc. Mg/L |
Initial Weight Grams |
Weight Change in 14 Days |
54929 |
5-12-62 8 Hours in 9-Liter Chamber |
0.3332 |
138 |
+44 |
54931 |
128 |
+10 |
||
54932 |
138 |
+32 |
||
54933 |
144 |
+21 |
||
54934 |
142 |
+40 |
||
54945 |
124 |
+42 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an Inhalation Hazard Test, no rats died after an 8 hour-exposure (whole-body) to an atmosphere saturated of isodecyl acrylate (0,3332 mg/L).
- Executive summary:
In an Inhalation Hazard Test, no rats died after an 8 hour-exposure (whole-body) to an atmosphere saturated of isodecyl acrylate (0,3332 mg/L). No LC50 was determined.
On the basis of this result, the substance does not warrant classification for an acute inhalation hazard.
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