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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1962
Report date:
1962

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Inhalation Hazard Test was performed.
GLP compliance:
no
Test type:
other: Inhalation Hazard Test
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Isodecyl acrylate
EC Number:
215-542-5
EC Name:
Isodecyl acrylate
Cas Number:
1330-61-6
Molecular formula:
C13H24O2
IUPAC Name:
2-methyloctyl prop-2-enoate
Test material form:
liquid

Test animals

Species:
rat
Strain:
other: Carworth Farms-Elias (Albino)
Sex:
female
Details on test animals or test system and environmental conditions:
no

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
Concentrated vapor, generated at approx. 21 °C by passind dried air at the rate of 2.5 liters/minute through a fritted glass disc immersed to a depth of al least one inch in 50 ml of isodecyl acrylate. The exposure period was eight-hours in a 9-liter chamber.
Duration of exposure:
8 h
Concentrations:
saturated vapour concentration
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
other: Inhalation risk test
Effect level:
ca. 333 mg/m³ air
Exp. duration:
8 h
Remarks on result:
other: No mortality occurred
Mortality:
No animals died.
Clinical signs:
other: All Animals appeared to be normal when removed from the inhalation chamber.
Body weight:
All animals gained weight during the subsequent 14-day observation period.
Gross pathology:
no
Other findings:
no

Any other information on results incl. tables

Single Inhalation by a Group of Female Allbino T´Rats of Concentrated Vapor Generated at approx. 21 °C.

Rat Number

Date and duration of Inhalation

Conc. Mg/L

Initial Weight Grams

Weight Change in 14 Days

54929

5-12-62

8 Hours in 9-Liter Chamber

0.3332

138

+44

54931

128

+10

54932

138

+32

54933

144

+21

54934

142

+40

54945

124

+42

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In an Inhalation Hazard Test, no rats died after an 8 hour-exposure (whole-body) to an atmosphere saturated of isodecyl acrylate (0,3332 mg/L).
Executive summary:

In an Inhalation Hazard Test, no rats died after an 8 hour-exposure (whole-body) to an atmosphere saturated of isodecyl acrylate (0,3332 mg/L). No LC50 was determined.

On the basis of this result, the substance does not warrant classification for an acute inhalation hazard.